摘要
目的:探讨重症肌无力伴胸腺瘤患者术后发生肌无力危象的危险因素。方法:回顾分析我院2002年6月至2011年12月因重症肌无力并胸腺瘤术后患者的临床资料。结果:75例患者中,术后发生肌无力危象13例(17.3%)。发生肌无力危象与患者Osseman分型高(P=0.010)、术前病程长(P<0.001)、术前溴吡斯的明用量大(P<0.001)、术前发生过肌无力危象(P<0.001)、术后肺部感染(P<0.001)、术后未早期应用血浆(P=0.012)有关。Osseman分型高(P=0.014)、术前溴吡斯的明用量大(P<0.001)和术后早期未应用血浆(P=0.033)是术后发生肌无力危象的独立危险因素。结论:Osseman分型高、术前溴吡斯的明用量大、术后未早期应用血浆的患者术后易发生肌无力危象。
Objective To evaluate the risk factors affecting the postoperative muscle weakness crises. Methods Analysed clinical data of patients with thymoma resection retrospectively. Results The patients with type of Osseman (P = 0.010), preoperative course (P 〈 0.001 ), dose of pyridostigmine (P 〈 0.001 ), happened muscle weakness crises before operation (P 〈 0.001 ), postoperative lung infection (P 〈 0.001 ) and without usage of plasma (P = 0.012) exerted effects on postoperative muscle weakness crises. Type of Osseman (P = 0.014), dose of pyridnstigmine before surgery (P 〈 0.001 ) and without usage of plasma (P = 0.033) were independent risk factors for muscle weakness crises. Conclusions Patients with high type of Osseman,large dose of pyridostigmine belbre surgery and without usage of plasma easy to have postoperative muscle weakness crises.
出处
《实用医学杂志》
CAS
北大核心
2013年第1期50-52,共3页
The Journal of Practical Medicine
关键词
胸腺瘤
重症肌无力
肌无力危象
Thymoma
Myasthenia gravis
Postoperative muscle weakness crises