摘要
为了研究女性激素与重症肌无力的关系,对月经期肌无力加重的36例重症肌无力(MG)病人作了月经前后女性激素的检测,发现月经前后的促卵泡生成素(FSH)、催乳素(PRL)、雌二醇(E2)、孕酮(P)的均值明显高于正常对照组。月经前的促黄体生成素(LH)低于正常组,但无统计学意义(P>0.05),说明LH对MG无影响。FSH影响较小。PRL、E2和P对MG有极大影响(P<0.001)。MG病人血清PRL值应在正常范围,这就提示MG病人月经期病情加重可能是PRL、E2和P的增高所致,说明血清PRL、E2和P的增高与肌无力加重有关,这两者之间是否为因果关系尚难肯定。
Amongthecaseswithmyastheniagravis(MG)two-thirdswerefemales.ThesereritywoulddeteriorateorleadtothedeathsoftheMGsuferers.Chenreportedthatfemalecasesexperiencedmorefrequentlythanthemales.InanattempttoinvestigatctherelationbetweenthechangesofthefemaleshormoneandthedeteriotionofMG,wedeterminedtheserumconcentrationoftheestra-diol(E2),progesterone(P),prolactin(PRL)andfolicle-stimulatinghormone(FSH)andluteinizinghormone(LH)in36femalesoftheagesbetween18and40yearsALLtheresultssuggestedthatthealterationsofthefemalehormonesmighthaverelationswiththedeteriorationofsomefemalecasesofMG.
出处
《中华神经科杂志》
CAS
CSCD
1996年第6期351-353,共3页
Chinese Journal of Neurology
关键词
重症肌无力
激素类
女性
病理
FemalehormoneMyastheniagravisRadioimmunoassay