摘要
自 1 9世纪以来的研究表明 ,在胚胎发育期间和出生后 ,包括人在内的哺乳动物神经系统的大部分神经细胞 (也许是所有神经细胞 )都要经过一定距离的迁移运动才能抵达它们发挥功能的部位。这些细胞如何知道往哪个方向迁移呢 ?我们在分子水平对这个问题进行了研究。 1 999年发表的结果给出这样一个答案 :脑内存在导向性分子 ,可以指导神经细胞的迁移方向 ;具体的发现是 ,一个叫Slit的分泌性蛋白质 ,对神经细胞有排斥性作用 ,它的浓度梯度指导神经细胞迁移的方向。
A large amount of work since the late 1800 have shown that, during embrynoic and postnatal development, the majority, if not all, neurons in mammalian nervous system have to migrate a certain distance to reach their final destination. An interesting question is how neurons are guided for their migration. We are interested in the molecular mechanisms underlying neuronal migration and our work published in 1999 indicates that there are diffusible molecules in the brain which can guide the direction of migrating neurons; specifically, a secreted protein called Slit is repulsive to neurons and its concentration gradient guides neuronal migration.
出处
《生理科学进展》
CAS
CSCD
北大核心
2000年第3期198-204,共7页
Progress in Physiological Sciences
