摘要
描述了四组大鼠六个训练期从四个释放点寻找圆形水迷宫(Morris)固定没水平台的动物行为实验。四组动物为 :脉冲微波组 (2450MHz ,调制脉宽2μs ,每秒500脉冲 ,空间平均功率密度为2mW/cm2 ,平均整体特异吸收率SAR ,1.2W/kg) ,连续微波组 (2450MHz ,无调制 ,空间平均功率密度和SAR同于脉冲微波组 ) ,Sham辐射组以及笼养对照组。以平均逃逸时间和速度为测量参量 ,考查它们的空间记忆和学习认知能力。发现不同组动物的生物行为效应存在较大差别 ,与处理条件和释放点相关。微波处理组大鼠弱于Sham和笼养对照组。训练期响应曲线的不同暗示大鼠采用不同空间行为战略寻找目标。脉冲微波处理组对大鼠的负作用强于连续微波组 ,并呈现电磁时间“窗口”效应。
Four groups of rats: pulsed microwave-exposed, continuous microwave-exposed (CW), sham-exposed (Sham) and cage control (CC),were trained in a circular water maze(Morris) to locate a submerged platform from four different orientated release points for six sessions. By use of their average escape time and speed as measuring parameters the rat's space learning and memory ability were studied. Pulsed rats were exposed to pulsed 2450 MHz microwave(pulse width 2μsec, 500 pulses per sec, power density 2mW/cm2, average whole body specific absorption rate,1.2W/kg) and CW rats to continuous 2450 MHz microwave (power density 2mW/cm2,average whole body specific absorption rate, 1.2w/kg) for 45 min in a circular wave-guide system immediately before each training session. It has been found that there exist much different effect of lehavior among the groups depending on the rat's treatment and release points. Data showed that microwave-exposed rats were slower than Sham and CC control rats. The difference between rat's response curves suggests that rats used their own strategy in learning the location of the platform. The exposure to pulsed microwave caused a more defieiency in spatial “reference” memory in rats and displayed a stronger electromagnetic “windows” effect in response curves than the exposure to CW microwave did.
出处
《生物物理学报》
CAS
CSCD
北大核心
2000年第2期413-420,共8页
Acta Biophysica Sinica
