摘要
目的 合成环丙沙星中间体 2 ,4 -二氯 - 5-氟苯甲酰氯。方法 以 1.3-二氯 - 4 -氟苯为原料 ,经取代 ,氧化 ,酰化三步反应制得。结果 反应条件温和 ,方法简单 ,总收率 6 9%。
Objective Synthesis of 2.4-dichloro-5-fluorobenzoyl as the intermediate of Ciproflxacin.Methods 1.3-dichloro-4-fluorobenzene as ran materical,reactions of substitution,oxidation,and acvlation were described.Results The reactions of all steps were carried out in moderate conditions to afford an overall yield of 69%.Conclusion This method was suitable for industrial preparation.
出处
《济宁医学院学报》
2000年第2期21-22,共2页
Journal of Jining Medical University
关键词
氟苯甲酰氯
合成
药物中间体
环丙沙星
2.4-dichloro-5-fluorobenzoyl chloridc
sythcsis
intcrmcdiatc for pharmaceuticals.
