摘要
目的:总结国内外关于microRNA(miRNA)的DNA甲基化在各肿瘤中的研究进展。方法:应用PubMed及CNKI全文数据库检索系统,以"miRNA、DNA甲基化和肿瘤"为检索词,检索2004-04-2012-05的相关文献,共检索到英文文献401篇,中文文献40篇。文献纳入标准:1)miRNA的生物学特性;2)DNA甲基化的作用机制及与肿瘤的关系;3)miRNA的DNA甲基化与肿瘤发生发展的关系。根据纳入标准符合分析的文献27篇。结果:miRNA在肿瘤发生发展中可发挥癌基因和抑癌基因的作用,DNA甲基化是肿瘤发生的一个重要因素。20%受甲基化调控的miRNA在上游5kb范围内有CpG岛,miRNA的DNA甲基化与CpG岛有密切关系。miR-34、miR-124、miR-9和miR-127的DNA甲基化在各种肿瘤中频繁发生,多数通过靶向调节癌基因或抑癌基因而在肿瘤发生发展中发挥作用。结论:miRNA的DNA甲基化在人类肿瘤中广泛存在,甲基化miRNA可能作为肿瘤早期诊断、治疗、转移和预后的分子标志。
OBJECTIVE：To review the recent progresses about microRNA（miRNA） regulated by DNA methylation in tumorsat home and abroad. METHODS： The literatures with “miRNA, regulated by DNA methylation and tumors” as key words were retrieved in PubMed and CNKI from 2004-04 to 2012 05. Total 401 English papers and 40 Chinese papers were obtained. The selection criteria： 1） the bionomics of miRNA; 2） the mechanism of DNA methylation and its relation- ship with tumors; 3） DNA methylation of miRNA in kinds of tumors. According to the critenia,27 papers were involved. RESULTS：miRNA can act as oncogene or antioncogene through DNA methylation in tumors. Totally 20% of miRNA reg- ulated by DNA metylation is with CpG Island inside in 5kb region,so DNA methylation of miRNA is closely related with CpG Island. miR-34 ,miR-124,miR-9 and miR-127 are frequently methylated in kinds of tumors,most of which play roles in tumor progression by targeting oncogenes or antioncogenes. CONCLUSION： miRNA regulated by DNA methylation widely exists in human tumors, and can be used in tumor early diagnosis, treatment, metastasis and prognosis.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2012年第24期1919-1922,共4页
Chinese Journal of Cancer Prevention and Treatment
基金
北京市教委科技计划面上项目(KM2010100-25022)
