摘要
目的:观察阿司匹林治疗老年冠心病患者24周对血小板聚集功能的影响。方法:选择临床需要服用阿司匹林抗血小板治疗,且ADP诱导的血小板聚集率增高的老年冠心病患者122例,给予阿司匹林100mg口服24周。用药前及用药6、12、24周后分别测定血小板聚集率。结果:服用阿司匹林后,患者的血小板聚集率显著降低,6、12、24周测定血小板聚集率与基线比较均差异有统计学意义(均P<0.01),血小板聚集抑制率分别为-(21.13±21.66)%,-(29.25±21.67)%,-(22.87±21.92)%。12周的血小板聚集率较6周进一步下降,但24周较12周则明显升高,两个差值均差异有统计学意义(均P<0.05)。结论:阿司匹林可明显降低患者的血小板聚集功能,但抗血小板聚集作用在24周后较12周有明显下降。
Objective：To observe the effect of 24 week treatment of aspirin on platelet aggregation in elderly patients with coronary heart disease. Method：The 122 senile patients with coronary heart disease were given aspirin100 mg orally for 24 weeks.Platelet aggregation was measured before and 6,12,24 weeks after administration. Result：The platelet aggregation was significantly inhibited 6,12 and 24 weeks after administration.There were significant differences in the platelet aggregation between baseline and post treatment.The inhibition rate of platelet aggregation at 6,12,24 weeks after administration were-（21.13±21.66）%,-（29.25±21.67）%,and-（22.87±21.92）%,respectively.The inhibition of platelet aggregation was more significant at 12 weeks than at 6 weeks follow-up,but less significant at 24 weeks than at 12 weeks follow-up（P0.05）. Conclusion：Aspirin inhibits platelet aggregation,but this effect is lower at 24 weeks than at 12 weeks.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2013年第1期14-16,共3页
Journal of Clinical Cardiology
基金
武汉市卫生局临床医学科研项目(No:WX08D05)
关键词
冠心病
阿司匹林
血小板聚集
老年
coronary heart disease
aspirin
platelet aggregation
elderly patient
