摘要
目的探讨长期口服小剂量阿司匹林对老年冠心病患者血小板活化功能的影响。方法116例冠心病患者随机分为ASA50组、ASA100组及对照组,运用流式细胞仪(FCM),准确测定各组经体外二磷酸腺苷(ADP)及花生四烯酸(AA)共同活化的血小板膜表面糖蛋白(GPⅡb/Ⅲa、CD62P)的阳性表达率,观察并分析比较老年人血小板膜表面糖蛋白的阳性表达率的变化。结果(1)血小板膜表面糖蛋白GPⅡb/Ⅲa的阳性表达率在ASA50及ASA100组分别为(64.40±15.71)%,(57.22±15.82)%,两种剂量阿司匹林均较对照组(75.8±15.71)%明显降低(P<0.05)。CD62P(P-Selectin)的阳性表达率分别为(68.01±9.57)%,(60.44±9.30)%,阿司匹林组与对照组(78.59±6.38)%比较明显降低(P<0.05)。(2)ASA50组与ASA100组两组间比较,PAC-1的阳性表达率为(64.40±15.71)%与(57.22±15.82)%,两组间差异无统计学意义(P>0.05);CD62P的阳性表达率为(68.01±9.57)%与(60.44±9.30)%,两组间差异亦无统计学意义(P>0.05)。结论小剂量阿司匹林可有效抑制血小板活化功能,每日服用50mg和100mg阿司匹林对血小板活化功能的抑制无显著差异,双相激活血小板可以客观反映体内阿司匹林对血小板活化功能的影响。
Objective To investigate the effects of lower dosages of Aspirin on the platelet activation in the elderly patients with coronary heart disease.Methods 71 elderly patients with coronary heart disease were divided randomly into three groups：ASA50,ASA100 and control group.The positive glycoprotein（GPⅡb/Ⅲa and CD62P）expression on the surface of platelets were assayed with Flow cytometry（FCM）in the different groups after the platelets were activated by adenosine diphosphate（ADP）and arachidonic acid（AA）together in vitro.The expression of GPⅡb/Ⅲa and CD62P on the surface of platelets in the different groups was also analyzed.Results The expression of GPⅡb/Ⅲa in ASA50 and ASA100 were（64.40±15.71）%,（57.22±15.82）%,and that of CD62P were（68.01± 9.57 ）%,（60.44±9.30）%,respectively.There were significant difference in both ASA50 and ASA100 after the study VS the control group[GPⅡb/Ⅲa（75.8±15.71）%,P0.05;CD62P（78.59±6.38）%,P0.05].There were similar significant expression about GPⅡb/Ⅲa and CD62P between ASA50 and ASA100[（64.40±15.71）% vs（57.22±15.82）%,P0.05;（68.01±9.57%）vs（60.44±9.30）%,P0.05].Conclusions Low dose of Aspirin can inhibit the ability of platelet activation of Aspirin in elderly patients.There is no significant difference in the inhibition of platelets activation between ASA50 mg/d and ASA100 mg/d.The double phases to activate the platelets is effective to define the ability of platelets activity.
出处
《中国临床保健杂志》
CAS
2010年第2期116-119,共4页
Chinese Journal of Clinical Healthcare
