摘要
目的：观察针箭颗粒的降压及改善高血压病（ＥＨ）胰岛素抵抗（ＩＲ）的作用。方法：将５２例ＥＨ患者随机分为治疗组３０例和对照组２２例，分别给予针箭颗粒和卡托普利治疗４周，观察治疗前后血压、空腹及餐后２ｈ血糖、胰岛素（放免法）、胰岛素敏感指数（ＩＳＩ）和血脂的变化，并与健康对照组１７名比较。结果：治疗前两组患者空腹胰岛素及餐后２ｈ血糖、胰岛素含量明显高于健康对照组（Ｐ＜ ０．０１），ＩＳＩ明显低于健康对照组（Ｐ＜０．０１），说明存在ＩＲ；治疗后不仅血压明显下降（Ｐ＜０．０５，Ｐ＜０．０１），而且空腹胰岛素，餐后２ｈ血糖、胰岛素均显著降低（Ｐ＜０．０５，Ｐ＜０．０１），ＩＳＩ显著升高（Ｐ＜ ０．０５，Ｐ＜０．０１），两组ＩＲ均得到改善，治疗组血脂也有明显改善。结论：针箭颗粒不仅具有确切的降压效应，而且对ＥＨ所伴有的代谢障碍特别是ＩＲ具有明确的改善作用。
Objective: To observe the effect of Zhenjian Granule (ZJG) in improving essential hypertension and insulin resistance (IR). Methods: The 52 patients of hypertension were randomly divided into the ZJG group (n=32) and the control group (n=20), treated with ZJG and captopril respectively for 4 weeks. The changes of blood pressure, glucose, insulin, insulin sensitivity index (ISI) and blood lipid in them before and after treatment were determined and compared with those in normal group (17 healthy subjects). Results: Fasting insulin, blood glucose, and insulin 2 hrs after meal in hypertension patients before treatment were significantly higher but ISI was significantly lower than those in the normal control, indicating the existence of insulin resistance. After treatment, not only blood pressure in patients obviously lowered, but also levels of fasting insulin, blood glucose, and insulin 2 hrs after meal obviously lowered, while ISI markedly raised. IR was improved in both groups, and blood lipid were also improved in the ZJG group. Conclusion: ZJG was effective in reducing blood pressure, also it had significant effect in improving metabolic disorder, particularly on IR in patients of essential hypertension.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2000年第7期511-514,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
江苏省科委资助课题!(No.BS98067)
关键词
高血压
胰岛素抵抗
针箭颗粒
临床研究
essential hypertension
insulin resistance
Zhenjian granule
