摘要
目的：探讨Ｐ１６蛋白在大肠癌中的表达及意义。方法：采用免疫组化ＡＢＣ法观察８０例大肠癌、大肠腺瘤及正常粘膜中Ｐ１６蛋白的表达情况。结果：大肠癌组织Ｐ１６蛋是性表达率为４０．０％，低于正常粘膜及腺瘤中的表达（Ｐ〈０．０５），其阳笥表达率在癌组织的分化程度、有无淋巴结转移及病人生存时间等方面有显著性差异（Ｐ〈０．０５）。结论：大肠癌组织中存在Ｐ１６蛋白的缺失和突变。
Objective:To investigate the expression of p16 protein in human colorectal carcinoma and its clinical implication.Method:The expression of p16 protein was determined by immunohistochemical method in 30 cases of human colorectal carcinoma,and compared with that in adenoma and normal mucosa.Results:The positive rates of p16 protein expression in the 30 cases were 40.0%.The expression level of p16 in cancerous tissue is lower than that in normal mucosa and adenoma (P<0.05).The positive rates of p16 expression in different pathological gradings\,post-operative survival (3 years) and lymph node metastasis showed significant difference(P<0.05).Conclutions:The deletion and mution of p16 protein exist in human colorectal carcinoma,and p16 protein plays and important role in proliferation and differentiation of colorectal carcinoma.
出处
《医师进修杂志》
2000年第7期16-17,共2页
Journal of Postgraduates of Medicine
关键词
P16蛋白
抑癌基因
大肠肿瘤
病理学
p16 protein
suppressor carcinoma gene
colorectal carcinoma
