摘要
目的临床观察盐酸氨基葡萄糖和依托芬那酯凝胶治疗膝骨关节炎(KOA)的疗效。方法 2010年6月-2012年2月,将354例KOA患者随机分为盐酸氨基葡萄糖组(A组)、依托芬那酯凝胶组(B组)和盐酸氨基葡萄糖+依托芬那酯凝胶组(C组)。A组为口服盐酸氨基葡萄糖,750 mg/次,2次/d,疗程6周;B组为依托芬那酯凝胶外用,2次/d,6周为1个疗程;C组为在A组的基础上同时加用B组的方法。结果 C组在改善行走疼痛、夜间静息痛、晨僵方面优于A、B组,A组优于B组,差异有统计学意义(P<0.05)。总有效率A组为79.65%,B组67.28%,C组89.38%,差异有统计学意义(P<0.05)。出现不良反应A组3例,B组3例,C组4例,均较轻微,无严重不良事件发生。结论盐酸氨基葡萄糖和依托芬那酯凝胶治疗KOA均安全、有效,联合应用时,疗效进一步增强。
Objective To observe the clinical effects of glucosamine hydrochloride and etofenamate gel in the treatment of knee osteoarthritis（KOA）.Methods From June 2010 to February 2012,354 patients suffering from knee osteoarthritis in the Department of Orthopedics of our hospital were randomly divided into three groups： the glucosamine hydrochloride group（group A）,etofenamate gel group（group B）,and the co-treatment with glucosamine hydrochloride and etofenamate gel group（group C）.Patients in group A took oral glucosamine hydrochloride at 750 mg once for 2 times every day for 6 weeks.Patients in group B used etofenamate gel 2 times every day for 6 weeks as a treatment course.Patients in group C were co-treated with the methods of group A and B.Results For the symptomatic improvement of joint pain at walking,rest pain at night,and morning stiffness after treatment,group C was better than group A and B,and group A was better than group B,and both differences were significant（P0.05）.The total effective rate was 79.65%,67.28% and 89.38% respectively in group A,B and C,and there was statistical differences among the three groups（P0.05）.Three patients respectively in group A and B,and 4 in group C reported mild adverse events.No severe adverse events were observed.Conclusions Both glucosamine hydrochloride and Chinese traditional medicine etofenamate gel are effective and safe for KOA.Co-treatment with glucosamine hydrochloride and etofenamate gel can further enhance the effect..
出处
《华西医学》
CAS
2012年第12期1800-1804,共5页
West China Medical Journal
