期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

类风湿关节炎中HIF-1的研究进展 被引量：2

暂未订购
导出
摘要 类风湿关节炎（RA）的病理特征是滑膜的增生及多种炎症细胞的浸润。滑膜衬里层的增生将造成滑膜血管和滑膜细胞之间的距离增加,超过了氧的弥散距离;此外,滑膜细胞的增生、炎症细胞的浸润及无功能血管网的形成都将增加耗氧量,这些都将造成受累关节滑膜的缺氧。缺氧是炎症性关节微环境的一个特征性表现。为了应对氧浓度的降低,
作者 彭勇 陈勇
机构地区 宁波大学医学院 宁波市第二医院
出处 《现代实用医学》 2012年第11期1314-1316,共3页 Modern Practical Medicine
关键词 类风湿关节炎 HIF-1 滑膜细胞 炎症细胞 病理特征 关节滑膜 耗氧量 血管网
分类号 R593.22 [医药卫生—内科学]
  • 相关文献

参考文献20

  • 1Brouwer E, Gouw AS, Posthumus MD, et al. Hypoxia inducible factor- 1-alpha (HIF- 1 alpha) is related to both angiogenesis and inflammation in rhetwnatoid atlhtifis[J]. Clin Exp Rhettmatol, 2009, 27(6):945-951.
  • 2WesWa J, Molema G, Kallenberg CG. Hypoxia inducible factor-I as regtdator ofangiogenesis in rhetanatoid a:hrifis therapeutic implications[J]. Curr Med Chem, 2010, 17(3):254-263.
  • 3etat P:lylhy:oxy:se domain enzyme-2 is the n:or pkayer in regula: hypoxic responses in rheumatoid arthritis[J]. Arthritis Rheum, 2012, 64(9):2856-2867.
  • 4Wei:a:nnA, Jc:sonRS. Biology of HIF-la[J]. Cell Death Differ, 2008, 15(4):621-627.
  • 5Lee JM, Lee WH, Kay HY, et al. Hemin, an iron-binding porphyrin, inhibits H1F-lct induction through its binding with heat shock protein 90[J]./nt J Cancer, 2012,130(3):716-727.
  • 6Luo W, Zhong J, Chang R, et al. Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia inducible factor (HIF)- 1 ct but Not HIF-2ct[J]. J Biol Chem, 2009, 285(6):3651-3663.
  • 7Bento CF, Femandes R, Ramalho J, et al. The clNgemne dependent ubiquitin ligase CHIP targets HIF- 1 ct for degradation in the presence ofmethylglyoxal[J].tl.oSO'e,2010,5(11).150-162.
  • 8Ehrismann D, Flashman E, Germ DN, et al. Studies on the activity oflhe hypoxia-inducible factor hyckoxylases using m oxygen consamption assay[J]. Biochem J, 2007, 401 ( 1 ):227-234.
  • 9F.Dayan, D.Roux, M.C.Brahimi-Hom, et al. Mazure, the oxygen sensor factor-inhibiting hypoxia-inducible factor-1 conlrols expression of distinct genes through the bifunctional Wanscriptional character ofhypoxia inducible factor [J]. Ca 20O6, 66(7):3688-3698.
  • 10Li SH, Chun YS, Lira JH, et al. yon Hippel Lindau protein adjusts oxygen sensing of the FIH asparaginyl hydroxylase[J]. Int J 13iochem Cell Biol, 2011, 43(5):795-804.

同被引文献23

  • 1Grover HS, Gaba N, Gupta A, et al and dental care considerations[J]. Rheumatoid arthritis: a review Nepal Med Coil J, 2011, 13 (2) : 74 -76..
  • 2Zhang Q, Wu J, Cao Q, et al. A critical role of Cyr61 in interleukin- 17-dependent proliferation of fibroblast-like synoviocytes in rheuma- toid arthritis [ J ]. Arthritis Rheum, 2009, 60 ( 12 ) : 3602 - 3612.
  • 3Ahn JK, Koh EM, Cha HS, et al. Role of hypoxia-inducible factor- 1 alpha in hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblast-like synoviocytes[ Jl. Rheumatology (Oxford), 2008, 47(6): 834-839.
  • 4Brouwer E, Gouw AS, Posthumus MD, et al. Hypoxia inducible factor-l-alpha (HIF-lalpha) is related to both angiogenesis and inflammation in rheumatoid arthritis[J]. Clin Exp Rheumatol, 2009, 27(6) : 945 -951.
  • 5Fan SS, Zong M, Zhang H, et al. Decreased expression of alpha- enolase inhibits the proliferation of hypoxia-induced rheumatoid arthritis fibroblasts-like synoviocytes [ J ]. Mod Rheumatol, 2015, 25(5) : 1 -7.
  • 6Hu F, Mu R, Zhu J, et al. Hypoxia and hypoxia-inducible factor- 1 alpha provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis[J]. Ann Rheum Dis, 2014, 73 (5) : 928 - 936.
  • 7Jeon CH, Ahn JK, Chai JY, et al. Hypoxia appears at pre-arthritic stage and shows co-localization with early synovial inflammation in collagen induced arthritis[ J]. Clin Exp Rheumatol, 2008, 26(4) : 646 - 648.
  • 8Li X, Wang Y, Li X, et al. Hypoxia-induced transcription factor 1 alpha: a potent driving force behind rheumatoid arthritis[J].Clin Exp Rheumatol, 2014, 32(5) : 760.
  • 9Muz B, Khan MN, Kiriakidis S, et al. Hypoxia. The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis[J]. Arthritis Res Ther, 2009, 11 ( l ) : 201.
  • 10Zhou M, Qin S, Chu Y, et al. Immunolocalization of MMP-2 and MMP-9 in human rheumatoid synovium[Jl. Int J Clin Exp Pathol, 2014, 7(6) : 3048 -3056.

引证文献2

二级引证文献12

现代实用医学
2012年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部