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RNA结合蛋白HuR的研究进展 被引量:4

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摘要 RNA结合蛋白HuR是胚胎致死异常视觉(ELAV)基因家族中的成员,又被称为类胚胎致死性异常视觉基因1(ELAV1)。ELAV家族目前已鉴定的成员包括HuR、HuB、HuC与HuD 4种,它们在细胞中主要通过基因的转录后调控机制来调节靶基因的表达,
作者 张岩 梅柱中
出处 《广东医学》 CAS CSCD 北大核心 2012年第24期3820-3822,共3页 Guangdong Medical Journal
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参考文献25

  • 1KIM H H, ABDELMOHSEN K, LAL A, et al. Nuclear HuR ac- cumulation through phosphorylation by Cdkl [ J]. Genes Dev, 2008, 22(13) : 1804 -1815.
  • 2胡跃云,辛彦.HuR与肿瘤发生发展及预后关系的研究进展[J].现代肿瘤医学,2010,18(7):1445-1448. 被引量:3
  • 3KULLMANN M, GOPFERT U, SIEWE B, et al. ELAV/Hu pro- teins inhibit p27 translation via an IRES element in the p27 5 'UTR [J]. Genes Dev, 2002, 16(23): 3087 -3099.
  • 4LAL A, MAZAN MAMCZARZ K, KAWAI T, et al. Concurrent versus individual binding of HuR and AUFI to common labile tar- get mRNAs[J]. EMBO J, 2004, 23(15) : 3092 -3102.
  • 5PULLMANN R J, KIM H H, ABDELMOHSEN K, et al. Analysis of turnover and translation regulatory RNA - binding protein ex- pression through binding to cognate mRNAs [ J ]. Mol Cell Biol, 2007, 27 ( 18 ) : 6265 - 6278.
  • 6DAVID G P, TAYLOR M A, PORT J D. Intracellular localization and interaction of mRNA binding proteins as detected by FRET [J].BMC Cell Biol, 2010, 11 : 69.
  • 7KIM H H, KUWANO Y, SRIKANTAN S, et al. HuR recruits let- 7/RISC to repress e - Mye expression [ J ]. Genes Dev, 2009, 23(15) : 1743 -1748.
  • 8KUNDU P, FABIAN M R, SONENBERG N, et al. HuR protein attenuates miRNA - mediated repression by promoting miRISC dis- sociation from the target RNA[ J]. Nucleic Acids Res, 2012, 40 (11) : 5088 -5100.
  • 9FAROOQ F, BALABANIAN S, LIU X, et al. p38 Mitogen - acti- vated protein kinase stabilizes SMN mRNA through RNA binding protein HuR[J]. Hum Mol Genet, 2009, 18(21) : 4035 -4045.
  • 10ABDELMOHSEN K, PULLMANN R J, IAL A, et al. Phospho- rylation of HuR by Chk2 regulates SIRT1 expression [ J 1. Mol Cell, 2007, 25 (4) : 543 - 557.

二级参考文献69

  • 1王俊,郭燕,章必成,陈正堂,高建飞,赵勇,向德兵.人抗原R与血管内皮生长因子-C在非小细胞肺癌中的表达及意义[J].中国肺癌杂志,2007,10(6):481-485. 被引量:1
  • 2孙方利,张华宁,高雪芹,刘慧玲,孙文琴,郭大东,徐忠法.大肠癌基质金属蛋白酶-9的表达及其与HuR蛋白表达的关系[J].中华消化杂志,2006,26(9):630-632. 被引量:2
  • 3Al-Ahmadi W, Al-Ghamdi M,Al-Haj L,et al. Mternative polyadenylation variants of the RNA binding protein, HuR : abundance, role of AU-rich elements and auto-regulation [ J ]. Nucleic Acids Res, 2009,37( 11 ) :3612-3624.
  • 4Ido K,Nakagawa T,Sakuma T, et al. Expression of vascular endothelial growth factor-A and mRNA stability factor HuR in human astrocytic tumors [ J ]. Neuropatho1,2008,28 (6) :604-611.
  • 5Denkert C, Weichert W, Pest S,et al. Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression [ J ]. Cancer Res ,2004,64 ( 1 ) : 189-195.
  • 6Lim SJ, Lee SH, Joo SH, et al. Cytoplasmic expression of HuR is related to cyclooxygenase-2 expression in colon cancer[ J]. Cancer Res Treat,2009,41 (2) :87-92.
  • 7Ma W J, Cheng S, Campbell C, et al. Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein [ J].J Biol Chem, 1996,271 (14) :8144-8151.
  • 8Nabors LB,Gillespie GY, Harkins L,et al. HuR,a RNA stability factor, is expressed in malignant brain tumors and binds to adenineand uridine-rich elements within the 3 'untranslated regions of cytokine and angiogenic factor mRNAs[ J]. Cancer Res,2001,61 (5) : 2154-2161.
  • 9Wang JG,Collinge M, Ramgolam V, et al. LFA-1-dependent HuR nuclear export and cytokine mRNA stabilization in T cell activation [ J]. J Immunol,2006,176(4) :2105-2113.
  • 10Fan XC, Steitz JA, Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs [ J ]. EMBO J, 1998,17 ( 12 ) :3448-3460.

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