摘要
目的 :利用褶合光谱仪中杂质限量检测功能对药物中杂质进行定量分析。 方法 :对药物杂质浓度采用变量变换后 ,与差谱点值作线性拟合 ,对杂质进行定量分析 ,并以测定苯酚中杂质间苯二酚含量为实例作验证。结果 :采用对数变换后作线性拟合 ,相关系数可达 0 .99,样品回收率在 90 %～ 10 0 %。结论 :本法灵敏度高 ,操作简单 ,为微量杂质的检测提供了一条有价值的途径。
Objective: To quantify drug impurity by the limitation detection of the convolution spectrum system. Methods: After different transformation, the impurity concentrations were used to fit linearity with the variance values in order to find the best method. The phenol and resorcinol system was used to demonstrate the results. Results: The best results were found after logarithm transforms. The correlation coefficient could be 0.99. The recovery could be 99% 100%. Conclusion: The above mentioned is a simple and high sensitive method. It will offer a valuable way for trace impurity detection.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2000年第3期260-262,共3页
Academic Journal of Second Military Medical University
基金
国家自然科学基金!( 85 0 74
关键词
褶合光谱仪
限量检测
药物
杂质
convolution spectrum system
limitation detection
