摘要
目的 探讨男性原发性干燥综合征 (pSS)的临床特点 ,了解男女性之间的差异。方法 分析 30例男性及 77例女性原发性干燥综合征的临床资料。结果 男性 pSS起病年龄 (47± 12 )岁 ,起病到确诊平均时间 (6 1± 6 )年 ,与女性组比较 ,差异无显著性。男性pSS组与女性组首发症状均表现多样化 ,但以口眼干燥、关节疼痛、肺间质纤维化、肾小管酸中毒及皮肤表现相对较多。与女性组比较 ,口眼干燥首发率低 ,肺间质纤维化首发率高 (P <0 0 5 )。临床表现比较 ,口眼干燥、肺间质纤维化、尿 pH >7 0、角膜荧光染色、唾液流率、RF及抗SSA抗SSB抗体 ,两组存在显著差异 (P <0 0 5 )。结论 男性 pSS与女性 pSS比较 ,其特点 :①口眼干燥症状出现较晚 ,发生率较低 ,症状较轻 ,而腮腺受损与女性无差别。②肺受损出现较早 ,肺间质纤维化发生率高。③RF及抗SSA抗SSB抗体阳性率较低。
Objective To assess the clinical features of primary Sjgren′s syndrome in male and female patients to understand the differences between them.Method Thirty male and 77 female patients with pSS were analyzed.Results The mean age at onset in men pSS was (47±12) years old,average time from onset to diagnosis was (6 1±6) years.Initial clinical features were various.Dry eyes and dry mouth,arthritis and arthralgia,pulmonary abnormalities,renal tubular abnormalities and rash were more common.Compared with female patients,dry eyes and dry mouth was less frequency, but pulmonary abnormalities were more common ( P <0 05).the frequency of dry eyes and dry mouth,pulmonary interstitial fibrosis, urine pH,cornea lesions,natural salivary flow rate,RF,anti SSA and anti SSB antibodies were significantly different between male and female patients ( P <0 05).Conclusion For male pSS patient,the clinical characteristics are:①dry eye and dry mouth appeared later and milder;②pulmonary abnormalities appeared earlier,and frequency of pulmonary interstitial fibrosis is higher;③positivity of RF,anti SSA and anti SSB antibodies are lower.
