摘要
目的观察格列美脲(GM)治疗2型糖尿病(DM)的有效性,并进行格列美脲治疗2型糖尿病的药理分析。方法选取本院收治的2型糖尿病患者162例,随机分为对照组和观察组。对照组80例,餐前30min口服格列喹酮,剂量90mg/d,3次/d。观察组82例,餐后立即口服格列美脲,剂量4mg/d,2次/d。两组疗程均为3个月。检测比较两组患者治疗前后的空腹血糖、餐后2h血糖、糖化血红蛋白等指标。结果两组患者治疗后各项检测指标均有较大改善,观察组改善更理想,两组治疗后各项检测指标改善差异有统计学意义(P<0.05)。结论格列美脲治疗2型糖尿病安全、易行、高效,药理分析则为格列美脲是临床上首选的磺脲类降糖药物之一提供了理论上的重要依据。
Objective To observe the effectiveness of Glimepiride（GM） in the treatment of type 2 diabetes mellitus（DM）,and carry out its pharmacological analysis.Methods One hundred and sixty-two cases of patients with DM were selected,and divided into control group and observation group randomly.80 cases in the control group were given Gliquidone by oral administration 30 min before meals,with a dose of 90 mg/d,3 times/d.82 cases in the observation group were given GM immediately after meals,with a dose of 4 mg/d,2 times/d.The course of treatment was both 3 months in the two groups.Indicators of FBG,P2hPG and HbA1c were detected and compared between the two groups.Results Measurement indicators all improved after treatment in both groups,while the improvement of the observation group was more ideal,with statistically significant differences（P 〈0.05）.Conclusion GM in the treatment of DM is safe,easy and efficient.Pharmacological analysis provides important theoretic basis that GM is one of the clinically preferred Sulfonylureas glucose-lowering drugs.
出处
《中国当代医药》
2012年第36期70-70,72,共2页
China Modern Medicine
关键词
格列美脲
2型糖尿病
临床疗效
药理分析
Glimepiride
Type 2 diabetes
Clinical effect
Pharmacological analysis
