摘要
目的探讨格列美脲治疗老年2型糖尿病(T2DM)的疗效及用药安全性。方法选择该院2010年1月至2011年8月收治的老年T2DM患者52例,控制并稳定患者的血压、血糖及血脂,于早餐前30min口服格列美脲1～4mg/次,1次/d,8周为1个疗程。比较治疗前后患者血糖、血脂、血压及体质量指数(BMI)。结果治疗后,显效26例(50.0%),有效22例(42.3%),无效4例(7.7%),总有效率为92.3%。治疗前后患者空腹血糖、糖化血红蛋白(GHbA1c)、餐后2h血糖、血脂及血压比较,差异有统计学意义(P<0.05),治疗前后BMI比较,差异无统计学意义(P>0.05)。结论格列美脲安全、有效,可作为老年T2DM患者的首选磺脲类降糖药物。
Objective To explore the therapeutic efficacy and safety of glimepiride in the treatment of elderly patients with type 2 diabetes mellitus（T2DM）. Methods 52 elderly patients with T2DM accepted treatment from January 2010 to August 2011 in our hospital were collected. The blood pressure, glucose and lipids of patients were controlled and sustained, and then glimepiride 1- 4 mg was administrated to patients 30 minutes before breakfast once daily with a treatment course of 8 weeks. The blood glucose, blood lipids,blood pressure and body mass index（BMI） of patients before and after treatment were compared. Results After treat ment, 26 cases（50.0 % ） showed significantly effective, 22 cases （42.3 %） effective, 4 cases （7.7 % ） invalid, with total effective rate of 92.3 %, Compared with the fasting blood glucose, glyeosylated hemoglobin Alc（GHbAlc）, 2-h postprandial blood glucose, blood lipids and blood pressure of patients before and after treatment, the differences demonstrated statistically significant（P〈0.05）, and there was no statistical difference between BMI of patients before and after treatment（P〉0.05）. Conclusion Glimepiride is safe and effective,and can be used as the first choice of antidiabetie drugs of sulfonylurea class for elderly patients with T2DM drugs.
出处
《重庆医学》
CAS
CSCD
北大核心
2012年第8期744-745,共2页
Chongqing medicine
基金
重庆市医疗特色专科建设项目经费资助
关键词
糖尿病
2型
老年人
血糖
人体质量指数
格列美脲
diabetes mellitus, type 2
aged
blood glucose
body mass index
glimepiride
