摘要
本文观察了国产聚肌胞(polyI:C)在小鼠体内抗瘤作用和免疫调节功能。结果表明,5mg/kg polyI:C对小鼠肉瘤180,Lewis肺癌和小鼠肝癌抑瘤率分别为37.3％、61.6％和44.2％。在免疫调节作用中,polyI:C在体内外均增加NK,Mφ和抗体依赖的Mφ活性。注射polyI:C后的小鼠血清较正常小鼠血清在体外对P_(388)细胞有较强的抑制DNA合成作用。polyI:C本身无明显细胞毒作用(100μg/ml抑制P_(388)细胞~3HTdR掺入率为16.5％)。实验提示polyI:C通过免疫调节发挥抗肿瘤作用。
The antitumor effects in murine transplanted tumors and immune res-pones of poly IC were studied. The inhibition rate of tumor growth of sarcoma 180, Lewis lung carcinoma and murine hepatocarcinoma were 37.3%, 61.6%, 44.7% respectively following 5mg/kg/d intraperitoneal injection for 8 days. Enhancement of natural killer (NK) activity of sptenic cells was shown in vivo and in vitro using 51Cr-labeled YAC-1 as target cell. Macrophage and antibody dependented macrophage were activated by poly I:C in vivo to C57BL/6 mice using 51Cr-labeted p815 cell as target cell. Poly I:C lacks a direct cytotoxic: activity. The serum of mice received poly I:C displyed stronger cytotoxic -effect than serum of normal mice.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1991年第3期173-176,共4页
Chinese Journal of Cancer
