摘要
本文观察了 PolyI:C(聚肌胞)的错配体PolyI:C_(12)U对感染致死剂量甲型流感病毒小鼠的保护效果。在病毒感染前先给予2次 PolyI:C_(12)U(5μg/g·次)腹腔内注射,并在病毒感染后连续用药,可明显推迟小鼠肺炎的出现时间,减轻肺部病变严重程度并使小鼠死亡率降低到50％以下。推测 PolyI:C_(12)U 的抗病毒作用可能与体内干扰素的诱生和自然杀伤细胞活性增强有关。
The protective role of PolyI:C12U (the mismatched analogue of PolyI:C) in mice intranasally inoculated with a lethal dose of influenza A virus was studied. Intraper-itoneal administration of 2 doses (5 μg/g/dose) of PolyI:C12U at 48 hours intervals before the virus inoculation and additional 6 to 12 doses at 24 hours intervals post infection could overtly delay the appearance of influenzal pneumonia, reduce the severity of the lung lesions and decrease the mortality rate of the infected mice to less than 50%. It is assumed that the antiviral effects of PolyI:C12U may be associated with its ability to induce interferon (IFN) production and the enhancement of natural killer (NK) cell activity.
出处
《上海免疫学杂志》
CSCD
北大核心
1990年第6期324-327,共4页
Shanghai Journal of Immunology
