摘要
本文应用6种胃癌单克隆抗体混合物,以酶联结合抑制法分别测定了47例胃癌、28例慢性浅表性胃炎,15例慢性萎缩性胃炎,27例消化性溃疡,14例食管癌者患者胃液中上述单抗的相应抗原MG-Ags的含量。以抑制率≥60％计算各组阳性率,分别为78.7％、14.3％、33.0％、14.8％、和7.1％。并在胃癌组中观察到,随着癌灶增大,MG-Ags含量增加。酶联结合抑制法操作简便,重复性、敏感性、特异性较好。用此法测定胃液中肿瘤相应抗原的MGs含量,有助于临床诊断,有助于判定病情进展,治疗效果和预后,也有助于在高危人群中检出胃癌。
The mixture of six murine monoclonal antibodies against gastric cancerwere used to detect the level of tumor-associated antigens in gastric juice by ELISA binding inhibition test In 47 cases of gastric cancer, 28 cases of chronic superficial gastritis, 15 cases of chronic atrophic gastritis, 27 cases of peptic ulcer and 14 cases of carcinoma of the esophagus, the positive rates were 78.7%, 14.3%, 33.0%, 14.8% and 7.1% respectively. It was also observed that inhibition rate was related to the size of gastric cancer. Owing to the simplicity and sensitivity of the procedure , it might serve as a preliminary screening test in the mass survey of gastric cancer and a mornitoring measure in the high risk subjects.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1991年第1期19-22,共4页
Chinese Journal of Cancer
关键词
胃肿瘤
单克隆抗体
诊断
Stomach neoplasms
Antibodies, monoclonal
Gastric juice
Enzyme-linked immunosorbent assay
Diagnosis.
