摘要
布氏菌是引起人和动物布鲁菌病的病原体。这类兼性胞内寄生菌表达一系列的致病因子,包括脂多糖、外膜蛋白和Ⅳ型分泌系统等以保持其毒力。有些致病因子是侵袭宿主所必需的,有些致病因子对逃脱宿主免疫系统的清除是必需的,它们保证了布氏菌在胞内的生存和增殖,逃脱宿主免疫系统的攻击。了解其致病因子和作用机制可为疫苗研制提供依据,也可促使新的抗生素研制。现就布氏菌致病因子的研究进展予以综述。
Brucella are the causative organisms of brucellosis in animals and humans.Brucella spp.are facultative intracellular pathogens that express a series of factors,including lipopolysaccharides,outer membrane proteins and type Ⅳ secretion system to ensure its virulence.Some virulence factors are necessary for host invasion,and some are necessary for Brucella to escape the host removal,which altogether allow Brucella to survive and multiply in the cells,escaping the host immune system attack.Understanding the pathogenic factors and mechanism may provide basis for the vaccine and promote the development of new antibiotics.Here is to make a review on the research progress of pathogenic factors of Brucella.
出处
《医学综述》
2012年第24期4125-4128,共4页
Medical Recapitulate
基金
内蒙古自然科学基金(2009MS1102)
内蒙古自治区科技计划项目
内蒙古卫生厅医疗卫生科研计划项目(2010018)
关键词
布氏菌
致病因子
脂多糖
外膜蛋白
Ⅳ型分泌系统
Brucella
Pathogenic factors
Lipopolysaccharide
Outer membrane proteins
Type Ⅳ secretion system
