摘要
目的探讨血液灌流(HP)联合复方α酮酸(α-KA)对维持性血液透析(MHD)患者微炎症状态及营养状况的影响。方法 MHD患者90例随机均分为三组,分别接受单纯血液透析(HD)(A组)、HP联合HD(B组)或HP联合HD并加用α-KA口服(C组)治疗。治疗前及治疗6个月后,结合临床症状进行营养不良-炎症反应评分(MIS),测量体重指数(BMI),测定C反应蛋白(CRP)、血浆白蛋白(Alb)、总胆固醇(TC)、血清肌酐(SCr)、尿素氮(BUN)和血红蛋白(Hb),计算尿素清除率(Kt/V)。结果治疗6个月后,B和C组MIS评分分别为(5.28±1.49)分和(3.36±1.10)分,均明显低于A组的(10.90±3.15)分(P<0.01)。B、C组Alb和Hb也较A组有明显升高,CRP则明显下降(P<0.05)。结论 HP联合α-KA治疗可明显改善MHD患者的营养状况,减轻微炎症状态。
Objective To study the effects of combined use of hemoperfusion and a-keto acid （a-KA） on microinflammation and nutrition status in the patients undergoing maintenance hemodilysis （MHD）. Methods Ninety MHD patients were equally randomized into three groups of A（hemodilysis alone） ,B（hemodilysis and hemoperfusion） and C（hemodilysis and hemoperfusion plus oral a-KA）. Malnutrition inflammation score （MIS）, body mass index （BMI）, C-reactive protein （CRP）, albumin （ Alb ）, total cholesterol （ TC ）, serum creatinine （ SCr ）, blood urea nitrogen （BUN）, hemoglobin （Hb） and Kt/V were determined before and at 6 months after treatment. Results After treated for six months,MIS scores in groups of B and C were （5.28q-1.49） points and （3. 36±1.10） points,which were remarkably lower than （10. 90±3.15） points in group A（P〈0. 01）. At the same time, Alb and Hb were higher, but CRP was lower, in groups of B and C than those in group A（P〈0.05）. Conclusion Hemoperfnsion and HP combined with a-KA can effectively ameliorate the malnutrition and mircroinfla in MHD patients.
出处
《江苏医药》
CAS
CSCD
北大核心
2012年第24期2967-2969,共3页
Jiangsu Medical Journal
