摘要
目的:探讨胚胎移植后14天与16天检测双次血人绒毛膜促性腺激素(β-HCG)及其倍数增长情况对妊娠结局的预测价值。方法:分析体外受精-胚胎移植助孕治疗的452例患者的临床资料,将妊娠妇女分为正常妊娠组(320例)、异常妊娠组(32例)、生化妊娠组(100例)。正常妊娠组包括单胎妊娠、双胎妊娠和三胎妊娠;异常妊娠组包括单胎停育和异位妊娠。比较胚胎移植后14天与16天血β-HCG浓度(简写HCG14d和HCG16d)的中位数水平及其倍数增长(简写HCG16d:14d)情况。结果:HCG14d与HCG16d的中位数水平从异常妊娠至正常妊娠逐渐增加。正常妊娠组的HCG14d、HCG16d及HCG16d:14d均明显高于异常妊娠组,差异有高度统计学意义(P=0.000),界值分别为380.59U/L、807.26U/L和2.10时均有中等预测价值;多胎妊娠组的HCG14d、HCG16d高于单胎妊娠组,差异有高度统计学意义(P=0.000),界值分别为1231.73U/L、3053.49U/L时有中等预测价值,其HCG16d:14d略高于单胎妊娠组,差异无统计学意义(P=0.857),界值为2.48时有较少预测价值;单胎停育组的HCG14d、HCG16d及HCG16d:14d均低于单胎妊娠组,差异均有统计学意义(P=0.034,P=0.001,P=0.000),界值分别为192.30U/L、366.46U/L和1.94时,分别有较少、中等、较高的预测价值;异位妊娠组的HCG14d、HCG16d及HCG16d:14d均低于单胎妊娠组,差异均有高度统计学意义(P=0.000,P=0.000,P=0.001),界值分别为110.36U/L、264.23U/L和1.97时分别有较高、较高、中等的预测价值。结论:胚胎移植后HCG14d、HCG16d定量检测结合其HCG16d:14d倍数增长可以预测正常妊娠、胚胎停育和异位妊娠。
Objective：To assess the predictive value of a double serum β-HCG determination combined with its multiple in pregnancy outcome after embryo transfer（ET）. Methods ：452 IVF-ET cases were enrolled in this analysis and included viable pregnancy group （320 cases）, non-viable pregnancy group （32 cases）, and biochemical pregnancy group （ 100 cases）. Viable pregnancy included single-pregnancy,twin-pregnancy, and triplet-pregnancy. Non-viable pregnancy included first-trimester miscarriage and ectopic pregnancy. The median of serum β-HCG level on 14^th day and 16^th day following ET and the multiple （HCG 16d： 14d ）were re- corded retrospectively. Results：The HCG14d 、HCG16d and HCG 16d： 14d in viable pregnancy group were all sig- nificantly higher than those in non-viable pregnancy group （ P = 0. 000）. The cut-off values of HCG14d, HCG 16d and HCG 16d： 14d were 380. 59 U/L,807.26 U/L,2. 10, respectively, which were all moderate predictive val- ues. The HCG14d and HCG16d in multiple pregnancy group were both higher than those in single pregnancy group（ P =0. 000）, and the cut-off values were 1231.73 U/L and 3053.49 U/L, respectively. The HCG 14d,HCG16d and HCG16d： 14d in first-trimester miscarriage group were all significantly lower than those in single pregnancy group （ P = 0. 034, P = 0. 001, P = 0. 000 ）. The cut-off values were little, moderately, highly predic- tive value respectively,which the HCG14、HCG 16d and HCG 16d： 14d were respectively 192.30 U/L,366.46 U/ L、1. 94. The HCG14d ,HCG16d and HCG 16d： 14din ectopic pregnancy group were all lower than those in single pregnancy group（ P = 0. 000, P = 0. 000, P = 0. 001 ）, and the cut-off values were highly, highly, moderately predictive value respectively, which the HCG 14d 、 HCG 16d and HCG 16d： 14d were respectively 110. 36 U/L 264. 23 U/L、1. 97. Conclusions.The serum β-HCG quantitative determination on day 14 and day 16 after ET combined with the multiple（ HCG 16d： 14d）might be of some prediction values to pregnancy outcome.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2012年第11期942-946,共5页
Journal of Practical Obstetrics and Gynecology
关键词
人绒毛膜促性腺激素
体外受精-胚胎移植
倍数
妊娠结局
In vitro fertilization and embryo transfer
Human chorionic gonadotrophin
Multiple
Pregnan-cy outcome
