摘要
目的:通过对早孕多胎妇女血清中β-绒毛膜促性腺激素(Beta-human chorionic gonadotropin,β-HCG)、人胎盘生乳素(Human placental lactogen,HPL)的测定,探讨其与多胎的关系。方法:动态监测门诊18例早孕多胎(包括2胎和3胎)妇女血清β-HCG、HPL的变化,随机选取同期本院门诊正常单胎早孕妇女35例作为对照,从孕5周开始,每2周检查1次血清β-HCG、HPL水平,至孕11周,观察相同孕周2组之间β-HCG、HPL的变化。结果:孕5～9周,多胎组血清β-HCG明显高于单胎组,差异有统计学意义(P<0.05);孕11周时,多胎组和单胎血清β-HCG差异无统计学意义(P>0.05);孕5周时,多胎组和单胎组HPL值差异无统计学意义(P>0.05)。孕7～11周,多胎组血HPL明显高于单胎组,差异有统计学意义(P<0.01)。结论:早孕时如β-HCG明显增高,结合HPL升高,应警惕多胎妊娠。
Objective： To explore the relationship between β-human chorionic gonadotropin（β-HCG）,human placental lactogen （HPL） and multiple pregnancies by measuring β-HCG and HPL in early pregnant women. Methods：The serum levels of β-HCG and HPL in 18 women with multiple pregnancies（including two and three fetuses） were measured every two weeks from the 5th week of pregnancy to the 11 th week; other 35 women with single fetus in the same period were taken as controls. Results：The serum level of β-HCG was significantly higher in multiple pregnancies group than in single pregnancy group during the 5-9th week of pregnancy （P〈0.05）. There was no significant difference in serum level of β-HCG between the two groups at the lltb week of pregnancy（P〉 0.05）. The serum level of HPL was not significantly different between the two groups at the 5th week of pregnancy（P〉0.05）. The serum HPL was significantly higher in multiple pregnancies group than in single pregnancy group（P〈0.01 ） during the 7-1 lth week of pregnancy. Conclusion：Obvious increase of β-HCG and HPL in early pregnancy indicates multiple pregnancies ,which should be alerted.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2012年第10期892-895,共4页
Journal of Chongqing Medical University
基金
重庆市卫生局资助项目(编号:2008-2-107)
关键词
早孕
Β-绒毛膜促性腺激素
人胎盘生乳素
多胎妊娠
early pregnancy
β-human chorionic gonadotropin
human placental lactogen
multiple pregnancies
