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唐山地区汉族人群IL-6-572C／G和TNF-α-238A／A基因多态性与脑梗死的关系 被引量：4

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摘要 目的探讨唐山地区汉族人群IL-6和TNF-α基因多态性分布特点及其与脑梗死的相关性。方法 PCR法和限制性片段长度多态性分析法比较正常人群与脑梗死组患者IL-6和TNF-α基因位点多态性的差异。结果脑梗死组患者IL-6-572C/G和TNF-α-238A/A的基因位点分布频率显著高于正常对照组(P<0.05)。结论唐山地区汉族人群IL-6-572C/G和TNF-α-238A/A基因位点多态性可能与脑梗死的发生相关。
作者 刘东芳 张宝琴 张振宇 陈晖 赵亚婷 张成侠 陈乃耀 王大力 冯志刚 刘艳芬 訾建杰
机构地区 河北省唐山市人民医院血液科 河北联合大学附属医院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2012年第24期5397-5398,共2页 Chinese Journal of Gerontology
基金 唐山市科学技术研究与发展计划指导项目(No.10310209a)
关键词 脑梗死 基因多态性 白介素-6 TNF-Α
分类号 R743 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献6

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共引文献8

同被引文献47

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引证文献4

二级引证文献11

中国老年学杂志
2012年 第24期

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