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唐山地区汉族人群脑梗死患者IL-6基因-174G/C多态性研究 被引量：2

The study on the interleukin-6 gene-174C/G polymorphism of cerebral infarction inTangshan Hans population
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摘要 目的探讨唐山地区汉族部分人群中IL-6基因-174C/G多态性与脑梗死的关系。方法采用多聚酶链反应-限制性片段长度多态法(PCR-RFLP)技术,检测118例脑梗死患者(病例组)和154例健康体检者(对照组)的IL-6基因-174C/G多态性位点频率,分析其基因型。结果脑梗死病例组与对照组IL-6-174G/C基因型全部为GG基因型,均未观察到CG和GG基因型存在。结论唐山地区汉族部分人群中不存在IL-6-174G/C基因多态性,-174位点的变异可能和脑梗死的发生、发展没有明确的关系。 Objective To investigate the relationship between interleukin-6 gene-174C/G polymorphism and cerebral infarction in Tangshan Hans population.Methods 118 patients with cerebral infarction and 154 normal people were recruited.All participants were genotyped for the interleukin-6 gene at the-174C/G locus using PCR-based restriction fragment length polymorphism method.Results Genotype of interleukin-6 gene-174 was all GG.Conclussion There was not interleukin-6 gene-174G/C polymorphism in Tangshan Hans population.Interleukin-6 gene-174C/G polymorphism may be not associated with susceptibility to cerebral infarction
作者 张江 王大力 陈乃耀 刘会英 李春玲
机构地区 华北煤炭医学院附属医院神经内科 华北煤炭医学院附属医院血液科 华北煤炭医学院附属医院老年病科
出处 《中风与神经疾病杂志》 CAS CSCD 北大核心 2010年第9期837-839,共3页 Journal of Apoplexy and Nervous Diseases
关键词 脑梗死 唐山地区 IL-6基因 多态性 限制性片段长度 基因频率 Cerebral infarction Tangshan area Interleukin-6 gene Polymorphism Restriction fragment length Gene frequency
分类号 R743.32 [医药卫生—神经病学与精神病学]
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参考文献12

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二级参考文献27

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中风与神经疾病杂志
2010年 第9期

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