期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肿瘤干细胞理论的演变 被引量：2

Evolution of Cancer Stem Cell Paradigm
暂未订购
导出
摘要 肿瘤干细胞(CSC)是存在于肿瘤组织或肿瘤细胞群中具有干细胞特性的亚群。CSC具有自我更新和分化能力,可以分化为特性各异的细胞。CSC因其强大的起始肿瘤能力和抵抗治疗的特性而成为关注的焦点。肿瘤干细胞理论从起初的单向等级分化模式,发展到现在的随机和等级分化交互模式,较好地解释了肿瘤在形态和功能方面的多样性,是研究肿瘤的发生和发展的理想模型。本文通过对近年来在肿瘤干细胞研究领域的部分卓越成就的解析,阐述了肿瘤干细胞在分化模式、微环境调控和动态变化等方面的特性。 Cancer stem cells （CSC） are a subset of cancer cells that share the characteristics of self-renewal capacity and multipotency with stem cells. CSC produces daughter cells with differential nature and thus contributes to tumor. The presence of CSC is associated with tumor initiation and therapy-resistance. The hierarchical and stochastic CSC model can explain the phenotypic and functional heterogeneity in various types of cancer. In this paper, recent excellent observations in CSC, including cell-lineage, regulation of microenvironment and dynamic equilibrium between CSC and non-CSC are reviewed.
作者 张雁
机构地区 中山大学生命科学学院
出处 《中山大学学报（医学科学版）》 CAS CSCD 北大核心 2012年第6期701-708,共8页 Journal of Sun Yat-Sen University:Medical Sciences
基金 国家重大科学研究计划项目(2010CB945400)
关键词 肿瘤干细胞 微环境 血管新生 细胞重编程 低氧 cancer stem cell microenvironment angiogenesis reprogramming hypoxia
分类号 R73 [医药卫生—肿瘤]
  • 相关文献

参考文献37

  • 1Hanahan D , Weinberg RA. Hallmarks of cancer: The next generation[J]. Cell, 2011, 144(5): 646-674.
  • 2Bonnet D, DickJE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell [J]. Nat Med, 1997, 3 (7): 730- 737.
  • 3Shi X, Zhang Y, ZhengJ, et a1. Reactive oxygen species in cancer stem cells [J]. Antioxid Redox Signal, 2012, 16(11): 1215-1228.
  • 4Chaffer CL, Weinberg RA. Perspective on cancer cell metastasis[J]. Science, 2011,331(6024): 1559-1564.
  • 5Chaffer CL, Brueckmann I , Weinberg RA, et al, Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state [J]. Proc Natl Acad Sci USA, 2011, 108(19): 7950-7955.
  • 6VisvaderJE, Lindeman GJ. Cancer Stem Cells: Current status and evolving complexities [J]. Cell Stem Cell, 2012, 10(6): 717-728.
  • 7Schepers AG, Snippert HJ, Stange DE, et a1. Lineage tracing reveals Lgr5 + stem cell activity in mouse intestinal adenomas [J]. Science, 2012, 337 (6095): 730-735.
  • 8Driessens G, Beck B, Caauwe A, et al. Defining the mode of tumour growth by clonal analysis [J] . Nature, 2012, 488(7412): 527-530.
  • 9Sachols E, Risueno RM, Bhatia M, et al. Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells [J]. Cell, 2012, 149 (6): 1284-1297.
  • 10ChenJ, Li Y, Yu TS, et al. A restricted cell population propagates glioblastoma growth after chemotherapy [J] . Nature, 2012, 488(7412): 522-526.

同被引文献43

  • 1Feng Li,Benjamin Tiede,Joan Massague,Yibin Kang.Beyond tumorigenesis: cancer stem cells in metastasis[J].Cell Research,2007,17(1):3-14. 被引量：86
  • 2Cabezas-Wallscheid N, Trumpp A. Stem cells. Potency finds its niches. Science. 2016;351 (6269):126-127.
  • 3Bautista W, Klein J, Cuvelier S, et al. Cancer stem cell invasion of the hepatic microvasculature as a predictor of tumour recurrence following surgical resection in adult patients with hepatocellular carcinoma. Can J Gastroenterol Hepatol. 2015;29(8):409.
  • 4Papadopoulou A, Kaloyannidis P, Yannaki E, et al. Adoptive transfer ofAspergillus-specific T cells as a novel anti-fungal therapy for hematopoietic stem cell transplant recipients: progress and challenges. Crit Rev Oncol Hematol. 2015.
  • 5Hayakawa Y, Ariyama H, Stancikova J, et al. Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastdc Epithelium and Are Supported by a Perivascular Stem Cell Niche. Cancer Cell. 2015;28(6): 800-814.
  • 6Wen Z, Feng S, Wei L, et al. Evodiamine, a novel inhibitor of the Wnt pathway, inhibits the self-renewal of gastric cancer stem cells. Int J Mol Med. 2015;36(6):1657-1663.
  • 7Brungs D, Aghmesheh M, Vine KL, et aI.Gastric cancer stem cells: evidence, potential markers, and clinical implications. J Gastroenterol. 2015.
  • 8Doherty MR, Smigiel JM, Junk D J, et al. Cancer Stem Cell Plasticity Drives Therapeutic Resistance. Cancers (Basel). 2016;8(1 ):8.
  • 9Valizadeh A, Ahmadzadeh A, Saki G, et al. Role of tumor necrosis factor-producing mesenchymal stem cells on apoptosis of chronic b-lymphocytic tumor cells resistant to fludarabine-based chemotherapy. Asian Pac J Cancer Prev. 2015; 16(18):8533-8539.
  • 10White PT, Subramanian C, Zhu Q, et al. Novel HSP90 inhibitors effectively target functions of thyroid cancer stem cell preventing migration and invasion. Surgery. 2016; 159(1 ): 142-151.

引证文献2

二级引证文献15

中山大学学报（医学科学版）
2012年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部