摘要
目的：探讨乳腺导管原位癌ｃ－ｅｒｂＢ－２、孕激素受体（ｐｒｏｇｅｓｔｅｒｏｎｅ ｒｅｉｅｐｔｏｒ，ＰＲ）表达与肿瘤组织学及预后的关系。材料和方法：选取无浸润成分的纯导管原位癌５６例，通过免疫组化测定其ｃ－ｅｒｂＢ－２、ＰＲ表达情况，然后分析其阳性表达与肿瘤组织学和预后的关系。结果：５６例中低分化导管原位癌２８例，中分化１５例，高分化１３例。高分化组 ｃ－ｅｒｂＢ－２、ＰＲ的阳性率分别为 ７．６９％， ９２．３１％ ；中分化组分别为 ２０％， ４６.６７％；低分化组分别为 ７０.４３％，１０.７１％。高、低分化组相比ｃ－ｅｒｂＢ２及ＰＲ表达均具有显著性差异（Ｐ＜０.０１）。５６例中２４例行单纯乳腺切除，１７例行改良根治术，病人术后无一例复发，５年存活率为１００％。１５例局部切除病例中，５例术后半年至１６个月内复发，其中低分化ＤＣＩＳ ３例，高、中分化各 １例，５例复发病例中 ｃ－ｅｒｂＢ－２阴性 １例，阳性４例。结论：导管原位癌组织学分级与 ｃ－ｅｒｂＢ－２、ＰＲ的表达具有密切关系：高分化ＤＣＩＳ ＰＲ表达率较高，而低分化ＤＣＩＳ ｃ－ｅｒｂＢ－２表达率较高。肿瘤预后与手术方式、组织学分级、ｃ－ｅｒｂＢ－２、ＰＲ表达均密切相关?
Objective: To clarify whether the prognosis of breast ductal carcinoma patient and histology related to expression of c-erbB-2, progesterone receptor(PR) of the tumor. Methods: A total of 56 cases of breast pure ductal carcinoma in situ(DCIS)were histologically and immunohistochemically studied. Results: Among 56 DCIS, 28 were poorly-differelltiated, 15 were intermediately-differentiated and 13 were well-differentiated. The positive expression rates of c-erbB-2 and PR were 7.69% and 92.31% in well-differentiated DCIS; 20% and 46.67% in intermediately-differentiated DCIS; 70.43% and 10.71% in poorly-differentiated DCIS, respectively. The positive rate was significently different between the poorly and well differentiated tumor (P<0.01). There were 24 cases received simple mastectomy and 17 underwent modified radical mastectomy. There were no recurrences among these patients and the 5-year survival rate was 100%. In 15 local excision cases, 5 had recurrence between 6-16 months following operation, in which 3 were poorly-differentiated, 1 intermediatelyand 1 well-differentiated. The expression of c-erhB-2 in the five recurrences were positive in 4 cases and negative in 1 cases. Conclusion:The histologic grade of DCIS correlates with the expression of c-erbB-2 and PR. The prognosis was closely related with histologic grade, surgical method and c-erhB-2, PR expression.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2000年第6期548-550,共3页
Chinese Journal of Cancer
