摘要
目的：有研究表明基质金属蛋白酶-７（ｍａｔｒｉｘ ｍｅｔａｌｌｏｐｒｏｔｅｉｎａｓｅ ７，ＭＭＰ７）与部分人肿瘤的浸润和转移有一定关系。本研究旨在探讨胰腺癌组织中ＭＭＰ７的表达及其在本病发展过程中的作用。材料与方法：用免疫组化染色方法检测了５１例胰腺癌石蜡包埋组织（其中２２例为早期病变，２９例为晚期病变）中ＭＭＰ７的表达。结果：５１例胰腺癌组织中３５例（６８.６％）显示有 ＭＭＰ７表达。而且，晚期胰腺癌 ＭＭＰ７表达的阳性率（７９.３％， ２３／２９）比早期（５４.５％，１２／２２）高，两组比较差异显著（Ｐ＜０.０５）。结论：胰腺癌组织中ＭＭＰ７的表达与肿瘤进展有一定关系，可被视为一种反映胰腺癌生物侵袭性的有价值的标志物。
Objective: Matrix metalloproteinase 7 (MMP7) is reported to be involved in the invasion and metastasis of some human tumors. In this study, we investigated the role of MMP7 in human pancreatic carcinoma (PC) progression. Materials and Methods: A total of 51 cases of PC, including 22 early lesions (clinical stage I and II) and 29 of advanced ones (clinical stage Ⅲ and Ⅳ ), were tested for MMP7 expression using immunostaining assay. Results: Increased MMP7 immunoreactivity was present in 35 (68. 6% ) cases of PC, and frequently distributed in the invasive front of the tumors. More cases expressed positive MMP7 in advanced group(23/29, 79.3% ) than in early group (12/22, 54. 5%; P < 0. 05 ). Conclusion: The increased expression of MMP7 was related to PC progression and might be considered to be useful as a marker for biological aggressiveness of this malignancy.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2000年第6期521-523,共3页
Chinese Journal of Cancer
基金
日本文部省癌研究重点基金
