摘要
高肺血流性肺动脉高压的形成主要是由于长期异常血流动力学改变引起肺动脉内皮损伤、肺动脉中膜平滑肌舒缩功能障碍和肺血管结构重构，进而使血管内径变小，肺血管阻力增加，其中肺动脉平滑肌收缩是重要的成因。
Pulmonary hypertension induced by high pulmonary blood flow involves a variety of complex mecha- nisms, including endothelial damage, pulmonary artery smooth muscle relaxation - contraction disorder and vascular remod- eling. Besides, the factor of ion channels in pulmonary artery smooth muscle ceils is also highly correlated to vasoconstric- tion. In recent years, many studies have shown that activation of Ca2＋ - activated Cl- channels is responsible for the mem- brane depolarization of pulmonary artery smooth muscle cells, and plays an important role in the regulation of vascular tone and vasoconstriction. This article reviews the biophysical and pharmacological characteristics of Ca2＋- activated Cl- chan- nels as well as the influence of Ca2＋- activated Cl - channels in high pulmonary blood flow - induced pulmonary hypertension.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2012年第12期2297-2300,共4页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.81160040)
关键词
钙激活性氯通道
肺动脉高压
肺动脉平滑肌细胞
尼氟灭酸
Ca2＋ -activated chloride channels
Pulmonary hypertension
Pulmonary artery smooth muscle cells
Niflumic acid
