摘要
目的:研究黄芩苷对氟喹诺酮类药物抗铜绿假单胞菌的协同作用。方法:以二倍稀释法测定药物的体外抗菌活性,筛选耐药菌,然后测定黄芩苷对4种氟喹诺酮类药物(诺氟沙星、环丙沙星、氧氟沙星、左氧氟沙星)抗铜绿假单胞菌的协同作用;以CCCP筛选存在主动外排系统的耐药菌,测定黄芩苷对4种氟喹诺酮类药物抗该类耐药菌的协同作用。结果:临床分离铜绿假单胞菌耐药现象普遍,黄芩苷联合4种氟喹诺酮类药物对耐药铜绿假单胞菌有协同抗菌作用,MIC值下降1-2倍。同时存在主动外排系统的耐药菌也表现出抗菌增敏作用。结论:黄芩苷与氟喹诺酮类药物联合应用对耐药铜绿假单胞菌有协同抗菌,对存在主动外排系统的耐药菌也表现出抗菌增敏作用。
Objective： To study the synergetie antibacterial effect of baicalin and 4 fluoxquinolones against Pseudomoruls aeruginosa. Methods： The synergetie antimicrobial effects of 4 fluoxquinolones （norfloxacin, ciprofloxacin, o{loxacin, levofloxacin） and baicalin against Pseudomonas aeruginosa were detected by double dilution method. CCCP was used as inhibitor for screening the resistant strains which have active efflux pump. Results： The combination of baicalin with 4 fluoxquinolones showed remarkable syn- ergetic antimicrobial effect on clinical isolated Pseudomonas aeruginosa, and the MIC decreased 1-2 folds. Baiealin also increased the anti-bacterial effect on resistant strains which have active efflux pump. Conclusion： The combination of Baiealin with 4 fluoxquinolones showed remarkable synergetic antimierobial effect on clinical isolated Pseudomonas aeruginosa.
出处
《四川生理科学杂志》
2012年第4期150-152,共3页
Sichuan Journal of Physiological Sciences
