摘要
目的采用近红外光谱技术比较早产儿和健康足月儿出生12～24 h脑组织氧合状况。方法对2011年4-6月南京大学医学院附属鼓楼医院妇产科收治的77例足月儿和2011年11月-2012年3月南京医科大学附属儿童医院新生儿医疗中心收治的61例早产儿进行出生12～24 h的脑组织氧饱和度(rSO2)监测,比较2组新生儿的临床情况及其与rSO2的关系。结果 2组新生儿分娩方式和性别比较,差异均无统计学意义(Pa>0.05)。2组新生儿胎龄、出生体质量及窒息(Apgar评分)比较,差异均有统计学意义(Pa<0.05)。2组新生儿的检测时间和外周血氧饱和度比较,差异均无统计学意义(Pa>0.05)。健康足月儿组的rSO2为(62.70±3.75)%,早产儿组rSO2为(64.66±3.93)%,二组比较差异有统计学意义(P=0.003)。健康足月儿组的动脉血二氧化碳分压[p(CO2)]为(5.26±0.36)kPa,早产儿组为(6.04±1.18)kPa,二组比较差异有统计学意义(P=0.000)。结论早期早产儿与健康足月儿相比,出生12～24 h的rSO2偏高,可能与该时期早产儿的脑血流丰富,动脉血p(CO2)分压偏高及脑组织的局部缺氧有关。
Objective To compare the brain regional oxygen saturation（ rSO2 ） in early stage of preterm newborns with that in healthy term newborns by using near - infrared spectroscopy. Methods There were 77 healthy term newborns enrolled in group A from Nanjing Drum Tower Hospital Affiliated to Nanjing University from Apr. to Jun. in 2011. Sixty - one preterm newborns enrolled in group B from Nanjing Children＇s Hospital Affiliated to Nanjing Medical University from Nov. 2011 to Mar. 2012. rSO2 were examined within 12 -24 hours after birth, and clinical conditions and relation with rSO2 were compared between the 2 groups. Results There was no significant difference between the 2 groups in delivery approach and gender（ P 〉 0.05 ）. There were significant differences in gestation age,birth weight and Apgar scores（ Pa 〈 0.05 ） between the 2 groups. There was no significant difference between the 2 groups in testing time and pulse oxygen saturation （P 〉 0. 05 ）. The rSO2 in group A was （62.70 ±3.75 ） %, and （64.66 ± 3.93 ） % in group B, with significant difference between the 2 groups （ P = 0. 003 ）. The p（ CO2 ） was （ 5.26 ± 0.36 ） kPa in group A, and （6.04 ± 1.18 ） kPa in group B, with significant difference between the 2 groups （ P = 0. 000 ）. Conclusions Compared with healthy term newborns, preterm newborns showed increased rSO2 within 12 - 24 hours after birth. This probably is due to the richer cerebral blood flow, higher p （CO：） and regional cerebral hypoxia during early stage after birth.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2012年第23期1830-1831,1840,共3页
Journal of Applied Clinical Pediatrics
基金
南京医科大学科技发展基金面上项目(2011NJMU129)
关键词
近红外光谱技术
脑组织氧饱和度
婴儿
新生
婴儿
早产
near - infrared spectroscopy
regional oxygen saturation
infant, newborn
infant, preterm
