摘要
简要介绍了枯草芽孢杆菌的生物特性及目前在环境领域的主要应用,阐述了枯草芽孢杆菌的群体感应信号系统及信号分子,指出群体感应在枯草芽孢杆菌生长过程中重要的调控机制。针对目前群体感应尚处于机制理论研究阶段,提出枯草芽孢杆菌群体感应系统在环境领域潜在的应用前景。
The present paper would like to introduce the biological features and main applications of Bacillus subtilis in brief and elabo- rate its quorum sensing system in a thorough-going way. As is known, Bacillus subtilis quorum sensing tends to display its function during the growth of late logarithmic and stationary stage, in which it is possible for its sensitive molecules to get synthesized in between their ceils and then would be brought out to the extracellular ones through the ATP-binding cassette. As is shown, the main signaling molecules may represent the ComX phermone and competence and sporulation factors in the process of quorum sensing in Bacillus sub- tills. We have already made a＇review over the ways of their genera- tion, the characteristic features and the likely roles in the regulation of quorum sensing system respectively. Since ComX pheromone is the main promoter for the development of gene＇ s mobility when it has ac- cumulated to a certain extent in the extracellular structures with the increasing number of bacteria, and their function of competence and sporulation factor are closely related to their intracellular concentra- tion. C, eneral^y speaking, the ~o＇~ concentration of competence and sporulation factor in the intracellular structures tend to promote the development of mobility, which in turn is likely to spore formation of high concentration due to the deterioration of nutritional conditions. And, it is for this reason, Bacillus subtilis can widely be used for degradation of pollutants in the field of environmental protection and sustainable maintenance through toxicity testing checking as strain of gram-positive bacteria in fighting against toxicity, though it has not been clear for its behavior. Quorum sensing is a very important regu- latory mechanism during the growth of Bacillus subtilis, however, current studies are mainly focused on exploring the theoretical prob- lems about the quorum sensing mechanism with scarce report on its applications. It is ~or this purpose that we would like to introduce quorum sensing into the field of environment protection, hoping to ex- pand its application to the environmental governance and toxicology. We are also inclined to extend its application into other related as- pects of environment to solve the related environmental protection areas. Moreover, we have also brought about some practical suggestions on how to disclose more encouraging application prospects in the near future.
出处
《安全与环境学报》
CAS
CSCD
北大核心
2012年第6期5-8,共4页
Journal of Safety and Environment
基金
国家自然科学面上基金项目(20977067,201177092)
中央高校基本科研业务费专项(0400219181)
同济大学污染控制与资源化研究国家重点实验室自主研究项目(PCRRY11003)
关键词
环境科学技术基础学科
枯草芽孢杆菌
群体感应
信号分子
应用前景
basic disciplines of environmental science and technolo- gy
Bacillus subtilis
quorum sensing
signaling molecules
apphcation prospects
