摘要
目的为进一步探究硝酸酯类制剂治疗不稳定型心绞痛的临床疗效及安全性,以达到合理使用硝酸酯类制剂的目的。方法回顾性分析我院2008-04—2012-01收治入院的不稳定型心绞痛患者100例临床资料,根据入院时间先后分为两组,每组50例,治疗组给予单硝酸异山梨酯片,对照组给予阿司匹林片。两组疗程均为4周。观察两组治疗前后临床疗效和心电图变化等情况,检测心功能指标,并予治疗后随访,记录药物的不良反应。结果两组患者治疗4周后,治疗组总有效46例(92.0%);对照组总有效35例(70.0%),两组临床疗效比较,差异有统计学意义(χ2=4.826,P<0.05);治疗组治疗后每搏量(SV)、心排血量(CO)、左室射血分数(LEVF)值明显高于对照组治疗后,且差异有统计学意义,P<0.05;两组治疗后均无肝、肾功能异常。结论硝酸酯类制剂治疗不稳定型心绞痛患者安全、有效。治疗时应注意合理使用药物,以达到良好的治疗效果。
Objective To further probe into the curative effects and safety quality of nitrate esters preparation on unstable angina pectoris so as to reasonably use nitrate esters preparation.Methods The clinical data of 100 sufferers with unstable angina pectoris admitted and treated in our sanatorium were analyzed through retrospective analysis.They were divided into two groups according to the admission time with 50 in each group.The treatment group were given isosorbide mononitrate while the control group were given aspirin tablets for four weeks.The clinical effects and changes of electrocardiogram among the two groups before and after the treatment were observed.Cardiac function indexes were checked and the adverse reactions of drugs were recorded during the post-treatment follow-up visits. Results After four weeks of treatment,46 in the treatment group were effective （92.0%）while 35 in the control group were effective （70.0%）.The differences of clinical effects between the two groups were of statistical significance （X 2 = 4.826, P〈 0.05）.After treatment, the values of SV, CO, and LEVF of the treatment group were clearly higher than those of the control group, and the differences were of statistical significance （P〈0.05）.There was no abnormal liver or renal function in the two groups after treatment.Conclusion It is safe and effective to use nitrate esters preparation to treat sufferers with unstable angina pectoris.Reasonable usage of nitrate esters preparation in treatment can reach good therapeutic efficacy.
出处
《中国疗养医学》
2012年第12期1078-1079,共2页
Chinese Journal of Convalescent Medicine
关键词
不稳定型
心绞痛
硝酸酯类制剂
安全性
合理使用
Unstable
Angina pectoris
Nitrate esters preparation
Safety
Reasonable usage
