摘要
目的:观察抗精神病药物引起精神分裂症患者的肝功能损害以及应用甘草酸二铵预防和治疗的可行性。方法:使用回顾性研究的方法,观察我院2001～2011年间住院的967例精神分裂症患者使用抗精神病药后引起肝功能损害的发生率以及使用甘草酸二铵(甘利欣)治疗肝功能损害的疗效,并使用卡方检验、logistic回归分析、t检验等方法来进行统计分析。结果:肝功能损害的发生率约为15.62%,肝功能异常的发生与连续服药的时间相关联,多在服药4周到6周左右,其中利培酮引起肝功能异常的发生率明显低于氯丙嗪,联合应用甘草酸二铵治疗,患者肝功能异常的发生率显著降低,且肝功能异常患者应用甘草酸二铵治疗后,大部分患者肝功能逐步恢复正常,疗效显著。结论:非经典抗精神病药物引起肝功能损害的发生率显著低于经典抗精神病药物,应用甘草酸二铵预防和治疗抗精神病药物所致肝功能损害有明确疗效。
Objective：To observe schizophrenia patients＇liver injury caused by antipsychotic drugs and the feasibility of using Diammonium Glycyrrihizinate to prophylaxis and cure liver function injury. Methods ：967 cases of schizophrenic patients from January 2001 to December 2011 in our hospital were retrospectively analyzed, using t test ,~2 test,logistic regression analysis to observe the rate of liver function injury caused by antipsychotic drugs and the curative effect of Diammonium Glycyrrihizinate. Results： The inci- dence of liver function injury was 15.62%, it~ associated with the continuous time that drugs taken; most of them took place in 4 -6 weeks after drugs taken. Obviously ,the rate of liver function injury caused by dispersal was much lower than chlorpromazine. The inci- dence of liver function injury was remarkably reduced by using Diammonium Glycyrrihizinate meanwhile, when patients find liver func- tion injury ,taking Diammonium Glycyrrihizinate orally, the liver function can bec6me normal gradually, the effect was remarkable. Conclusions： The incidence of liver function that induced by atypical antipsychotic drugs was less than induced by classical drugs. The curative effect of Diammonium Glycyrrihizinate to prophylaxis and treat liver function injury caused by antipsychotic drugs was conclu- sive.
出处
《中国民康医学》
2012年第23期2830-2832,共3页
Medical Journal of Chinese People’s Health
关键词
精神分裂症
肝功能损害
甘草酸二铵
利培酮
氯丙嗪
Schizophrenia
Liver function injury
Diammonium Glycyrrihizinate
Risperdal
Chlorpromazine
