摘要
评价生物可降解性材料聚 -β-羟基丁酯在动物体内的急、慢性全身毒性。方法 :参照 ISO对医用植入材料的评价标准和所推荐的生物学试验 ,对 PHB进行其浸出液经静脉注射后的急性全身性毒性反应和 PHB长期埋植动物体内血液常规、血液生化指标的观察。结果 :PHB在动物体内的急性全身性毒性反应为无毒 ,慢性长期埋置 PHB在动物体内不引起明显的血液常规、血液生化学的改变。结论 :新型可降解材料 PHB具有优良的生物相容性及安全性。
Objective:To evaluate the acute and chronic general toxicity to a new biodegradable PHB. Methods:According to ISO about biological evaluationand and test of medical materias. We carried out a systemic biological evaluation of domestic medical PHB including acute general toxicity and embeded under skins for long time to proceed the blood routine examination and serum biochemical tests. Result:The acute general toxicity of PHB is nearly no The chronic general toxicity of PHB embedding suggest no significative changes in the blood routine examination and serum biochemical tests.Conclusion: The result showed that this new medical biodegradable PHB has good biocompatibilty and biological safety.
出处
《中国美容医学》
CAS
2000年第3期164-166,共3页
Chinese Journal of Aesthetic Medicine
基金
国家"8 6 3"计划新材料领域资助! (715 -0 0 4-0 16 0 )
关键词
生物可降解材料
PHB
全身毒性试验
生物相容性
Biodegradable material PHB General Toxicity Biocompatibility Biological safety
