摘要
目的探讨瑞舒伐他汀对老年急性ST段抬高型心肌梗死(STEMI)患者行急诊经皮冠状动脉介入(PCI)术后再狭窄的影响。方法选取206例行急诊PCI的老年STEMI患者,依据术后服用他汀类药物的不同,分为A、B两组。A组101例给予瑞舒伐他汀钙10 mg,1次/晚;B组105例给予阿托伐他汀10 mg,1次/晚。观察术前、术后第1天、术后1、3、6个月总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高敏C-反应蛋白(hs-CRP)水平的变化情况,并于术后6个月复查冠脉造影。结果 A组术后3个月、6个月的血清TC水平分别为(4.12±0.81)mmol/L、(4.10±0.78)mmol/L,B组分别为(4.38±0.82)mmol/L、(4.33±0.76)mmol/L,两组间差异均有统计学意义(P<0.05)。A组术后3个月、6个月的血清LDL-C水平分别为(2.22±0.85)mmol/L、(2.20±0.87)mmol/L,B组分别为(2.51±0.86)mmol/L、(2.49±0.82)mmol/L,两组间差异均有统计学意义(P<0.05)。A组术后1个月的血清hs-CRP水平为(3.78±1.56)mg/L,B组为(4.48±2.52)mg/L,两组间差异有统计学意义(P<0.05)。术后6个月,A组的支架内最小管腔内径(MLD)为(3.06±0.34)mm,B组为(2.96±0.27)mm,两组间差异有统计学意义(P<0.05)。结论瑞舒伐他汀与阿托伐他汀相比,降脂效果更为明显;瑞舒伐他汀与阿托伐他汀均可减轻PCI术后的炎性反应,但瑞舒伐他汀较阿托伐他汀有更好的急性抗炎作用,对防治支架内再狭窄有一定作用。
Objective To investigate the effect of rosuvastatin on restenosis after emergency percutaneous coronary intervention（PCI） in old patients with ST-segment elevation myocardial infarction（STEMI）.Methods Totally 206 elderly patients with STEMI,who underwent emergency PCI,were divided according to their different medications of tatins after operation into two groups：group A of 101 patients received rosuvastatin 10 mg and group B of 105 patients received atorvastatin 10 mg,once at bed-time every day.Before PCI,1,3,and 6 months after PCI,the patients′ changes of serum total cholesterol（TC）,low-density lipoprotein cholesterol（LDL-C）,and high sensitivity C-reactive protein（hs-CRP） were examined,and coronary arteriography（CAG） was also conducted 6 months after PCI.Results The serum TC levels 3,6 months after PCI were（4.12±0.81）mmol/L and（4.10±0.78）mmol/L respectively in group A,as compared with（4.38±0.82）mmol/L and（4.33±0.76）mmol/L in group B,the differences were significant（P0.05）.The serum LDL-C levels 3,6 months after PCI were（2.22±0.85）mmol/L and（2.20±0.87）mmol/L respectively in group A,and（2.51±0.86）mmol/L and（2.49±0.82）mmol/L in group B（P0.05）.The serum hs-CRP level one mongth after PCI was（3.78±1.56）mg/L in group A and（4.48±2.52）mg/L in group B,with a significant difference（P0.05）.After 6th month CAG re-examination showed that in-stent minimal lumen diameter（MLD） was（3.06±0.34）mm in group A and（2.96±0.27）mm in group B（P0.05）.Conclusion Rosuvastatin,compared with atorvastatin,has a better effect in lowering blood lipid.Both can reduce inflammatory reaction after PCI,but rosuvastatin is better,and it has a certain effect to prevent and treat the restenosis after PCI.
出处
《中国全科医学》
CAS
CSCD
北大核心
2012年第31期3620-3623,共4页
Chinese General Practice
