摘要
目的 探讨雷帕霉素药物洗脱支架 (cypherTM)在急性ST段抬高心肌梗死 (STEMI)急诊经皮冠状动脉介入治疗 (PCI)中应用的安全性和有效性。方法 选择 2 0 0 2年 11月至 2 0 0 4年 2月的STEMI患者 96例 ,随机分为两组 :药物洗脱支架组 ( 4 8例 )和普通支架组 ( 4 8例 ) ,所有患者均于发病12h内行急诊PCI治疗 ,一组置入cypherTM ,另一组置入普通支架。结果 96例患者急诊PCI治疗均获得成功。 4 8支梗死相关血管 (IRA)的 4 8处罪犯病变置入 4 9枚药物洗脱支架 ,另 4 8支IRA的 4 9处病变置入 4 9枚普通支架。未发生与介入治疗有关的并发症 ,其中 1例置入cypherTM 者术后出现脑梗死 ,于第 7天死于多器官功能衰竭。药物支架组和普通支架组相比较 ,PCI后造影结果和临床结果差异均无显著性。随后对 95例病人进行了 1～ 9个月随访 (平均 4 5± 2 6个月 ) ,药物支架组患者未发生任何心血管事件 ,普通支架组有 2例发生心绞痛。结论 cypherTM
Objective To investigate the feasibility, safety and efficacy of cypher TM drug eluting stent implanting in patients with ST segment elevated myocardial infarction (STEMI) receiving emergency percutaneous coronary intervention (PCI) Methods From November, 2002 to Feburary, 2004, a total of 96 patients with STEMI were randomly enrolled into two treatment groups: cypher TM drug eluting stent (DES) group (48), and conventional stainless steel stent group (48), and received emergency PCI within 12 hours from the beginning of the heart attack Results 49 stents were implanted into 48 lesions in each group, the success rate was 100%, and there′s no complication accurred during the procedure in both groups One patient in the DES group had celebral infraction after the procedure and died of multiple organ failure seven days later There was no significant difference between the two groups on the instant angiographic and clinical outcomes 95 discharged patients were followed up for a period of 1 to 9 months (4 5±2 6) Two patients in the NDES group experienced angina pectors, whereas no major adverse cardiac event (MACE) was found in the DES group Conclusion Implanting of cypher TM drug eluting stent in STEMI patients receiving emergency PCI was as safe and effective as that of conventional stainless steel stent
出处
《中国介入心脏病学杂志》
2004年第2期67-70,共4页
Chinese Journal of Interventional Cardiology
