摘要
目的探讨食管动力异常与食管黏膜损害及酸反流发生的临床相关性。方法选择笔者所在医院2011年6月～2012年6月收治的符合胃食管反流病诊断标准的148例患者以及15名其他受试者纳入研究,均接受食管压力和食管24hpH值测定,GERD患者根据压力分组,其他受试者纳入对照组,对所有受试者食管压力以及24h食管pH值进行比较分析。结果 52例(35.1%)患者符合下食管括约肌低压标准,49例(33.1%)患者符合食管无效动力标准,33例(22.3%)患者两项均符合,14例(9.5%)患者两项均不符合。对照组的LESP要显著高于其他四组,差异有统计学意义(P<0.05);C组在远端反流指数、总反流时间、最长反流时间和EAC方面均显著高于A、B和D组,差异有统计学意义(P<0.05);B和C组在pH<4总时间百分比、立位pH<4时间百分比和卧位pH<4时间百分比方面显著高于其他3组,差异有统计学意义(P<0.05),而B和C组间差异无统计学意义(P>0.05)。结论胃食管反流病的发生与多因素有关,下食管括约肌低压和食管无效动力都是诱发因素之一,其中反流性食管炎的程度与酸反流密切相关,而与食管无效动力无相关性。
Objective To instigate the relationship between esophageal dysmotility and gastroesophaeal reflux disease.Methods 148 patients with GERD and 15 other people of our hospital from June 2011 to June 2012 were selected and tested by esophageaI manometry and 24 h pH monitoring.148 patients were grouped by esophageaI manometry,and healthy people as control group,all the esophageaI manometry and 24 h pH monitoring results were compared.Results 52 patients（35.1%） were complied with standard of LES low pressure.42 patients（33.1%） were complied with standard of IEM.33 patients（22.3%） were complied with both,and 14 patients（9.5%） complied neither.The LESP of control group were significantly higher than other four groups（P0.05）,and distal reflux index,total reflux time,longest reflux time and EAC of group C were the higher than group A,B and D（P0.05）.The total,orthostatic and supine percentage time of pH below 4 of group B and C were the highest（P0.05）,and there was no difference between group B and C（P0.05）.Conclusion The incidence of GERD has multi-factors.LESP and IEM are one of the predisposing factors.The degree of reflux esophagitis are closely related to acid reflux and have no correlation with IEM.
出处
《中国医药科学》
2012年第22期12-13,18,共3页
China Medicine And Pharmacy
关键词
胃食管反流
食管括约肌低压
食管无效动力
Gastroesophaeal reflux disease
Esophageal sphincter low pressure
Esophageal invalid power
