摘要
目的:分析胆道系统恶性肿瘤根治术后患者临床病理特点及预后影响因素。方法:回顾性分析116例于2006年1月至2010年12月在天津医科大学附属肿瘤医院接受R0手术切除的胆道系统恶性肿瘤患者预后相关因素,进一步评估不同部位胆道系统恶性肿瘤临床病理特征及辅助化疗获益情况。结果:单因素分析表明发病时肝侵犯、组织分化程度、神经血管浸润、淋巴结转移、TNM分期和化疗与否是影响胆道系统恶性肿瘤术后患者预后因素。多因素分析表明组织分化程度和化疗与否可作为独立的预后影响因子。不同部位胆道系统恶性肿瘤化疗获益情况不尽相同。结论:组织分化程度与化疗与否为胆道系统恶性肿瘤术后患者独立预后因素。不同部位的胆道系统恶性肿瘤生物学行为不尽相同,需要分别进行研究。
Objective： This work aimed to analyze the clmlcopatnologmai patients who had undergone surgery. Methods： The medical records of 116 patients with biliary tract cancer who had undergone radical surgery in Tianjin Cancer Hospital between January 2006 and December 2010 were retrospectively analyzed. The clinicopathological characteristics and prognostic factors were analyzed. Results： Univariate analysis revealed that the liver invasion, tumor grading, lymphaticl vascular invasion, lymph node staging, tumor - node - metastasis classification of the World Health Organization, and adjuvant chemotherapy were associated with the prognosis of these patients. Multivariate analysis revealed that the tumor grades and adjuvant chemotherapy were the independent prognosis factors. The responses to adjuvant chemotherapy also varied with the tumor location. Conclusion： Tumor grading and adjuvant chemotherapy were independent prognosis factors of biliary tract cancer patients. Their biological behaviors and responses to adjuvant chemotherapy varied with the tumor location. These behaviors and responses may need to be separately considered and analyzed for effective individualized treatment.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2012年第22期1849-1852,共4页
Chinese Journal of Clinical Oncology
关键词
胆系恶性肿瘤
预后
临床病理
辅助化疗
Biliary tract cancer
Prognosis
Clinicopathological factors
Adjuvant chemotherapy
