摘要
为探索补肺益肠方治疗溃疡性结肠炎的作用机制 ,分别采用冰乙酸和兔抗血清建立大鼠创伤性及免疫性溃疡结肠炎两种模型 ,观察该方 (党参、黄芪、桑白皮、紫菀、乌梅、五味子、血竭 )对模型大鼠结肠粘膜组织病理学、结肠损伤分数、红细胞超氧化物歧化酶 (SOD)、结肠粘膜过氧化脂质 (LPO)和大便乳酸含量的影响。结果 :治疗组大鼠结肠粘膜光镜下组织学有明显改善 ,结肠损伤分数、大便乳酸含量降低 ,SOD升高 ,LPO降低 ,与对照组比较 ,有显著性差异 (P <0 0 1,P <0 0 5)。提示补肺益肠方可通过降低结肠粘膜LPO含量 ,增加红细胞SOD含量 ,增强机体对O- 2 的清除 ,从而达到促进大便乳酸排泄 ,减少结肠炎症损伤的治疗作用。
HT6SS] To investigate the mechanism of“Lung intestine Nourishing Decoction”in the treatment of ulcerative colitis(UC),two kinds of model respectively of traumatic ulcerative colitis and immune ulcerative colitis in rats were established by ice acetic acid and rabbits antiserum.The pathology of colic mucosa,colic injury score,super oxide dismutase(SOD) of RBC,lipid of peroxide(LPO)of colic mucosa and the content of lactic acid in motions were detected before and after treatment by“Lung intestine Nourishing Decoction”(comprising Dangshen,Astragalus root,Mulberry bark,Tatarian Aster root,Schisandra fruit,Dragons blood,etc).Results showed obviously improved colic mucosa under light microscope,reduced injury score and less lactic acid in motions,elevated SOD and decreased LPO in model groups;compared with control group,there were great differences( P <0 01, P <0 05).The results revealed that the Decoction could promote the discharge of lactic acid and abate colitis by reducing the content of LPO,increasing the concentration of SOD and eliminate free radical O - 2. [HT6ZY]
出处
《上海中医药杂志》
北大核心
2000年第6期10-12,共3页
Shanghai Journal of Traditional Chinese Medicine
关键词
补肺益肠方
溃疡性结肠炎
中医药疗法
大鼠
HT6SS] “Lung intestine Nourishing Decoction”
Ulcerative colitis
experimental research
