摘要
目的 :研究血管紧张素转换酶 (ACE)基因多态性与 2型糖尿病并发高血压的关系。方法 :应用 PCR方法分析 149例 2型糖尿病患者及正常对照者的 ACE基因型。结果 :1ACE基因型及等位基因构成比 ,正常对照组与 2型糖尿病组无显著性差异 ;2并发高血压组 DD型及 D等位基因频率显著高于无高血压组 (P <0 .0 5 )。结论 :ACE基因 I/ D多态性与 2型糖尿病并发高血压有关。
Objective:To clarify if ACE gene polymorphism attributes to the development of hypertension in type 2 diabetic mellitus.Method:Angiotensin converting enzyme gene (ACE) genotypes were detected with PCR method in 149 patients with type 2 diabetic mellitus and 100 normal controls who were all ethnical Han people from Hebei province.Result:①No significant differences were found in the genotype distribution between 149 type 2 diabetic mellitus and 100 normal controls.②The DD genotype frequency was significantly higher in hypertension group than that in type 2 diabetic mellitus without hypertension (P< 0.05 ).Conclusion:ACE gene polymorphism attributes to development of hypertension in type 2 diabetic mellitus in ethnical Han people in Hebei province.
出处
《临床心血管病杂志》
CSCD
北大核心
2000年第6期259-261,共3页
Journal of Clinical Cardiology
基金
河北省科委资助!项目(No.98276193D
关键词
血管紧张素转换酶
糖尿病
高血压
基因多态性
Angiotensin converting enzyme Gene type Diabetes mellitus
non insulin dependent Hypertension
