摘要
目的 :观察拉西地平对轻、中度原发性高血压 (EH)的降压疗效及其安全性。方法 :采用自身对照开放试验方法。12 0例 EH患者 ,服安慰剂 1周后口服拉西地平 4～ 8m g(6 5 %服 4～ 6 m g)共 6周 ,不服其他降压药。观察血压、心率及各项实验室检查指标的改变。结果 :服药 6周后血压为 (144 .1± 14) / (85 .9± 7) m m Hg(1m m Hg=0 .133k Pa) ,收缩压下降 2 6 .9mm Hg,舒张压下降 15 .8mm Hg。显效 5 4例 ,有效 5 6例 ,总有效率 91.7%。有不良反应者 14例 (11.6 % ) ,主要为头晕、头痛、面红、心悸等 ,症状较轻不需停药。治疗前后各项血液生化、肝肾功能无改变。结论 :新型长效血管高选择性钙拮抗剂拉西地平对轻、中度 EH患者具有降压作用 ,不良反应少 ,耐受性好。
Objective:To observe the efficacy and safety of lacidipine on mild to moderate essential hypertension.Method:By the open self control,120 essential hypertension patients (male 83,female 37;28~68 y) were enrolled in this study.After a one week placebo run in period,they received lacidipine 4~8 ( 6.1 )mg daily (4~6 mg for 65%) for six weeks without any other antihypertensive drugs.Result:After six weeks of lacidipine treatment,the average blood pressure (BP) was reduced from ( 171.0 ± 15.0 )/( 101.7 ± 7.7 ) mmHg to ( 144.1 ±14)/( 85.9 ±7)mmHg.The systolic BP was reduced by 26.9 mmHg and the diastolic BP was decreased by 15.8 mmHg. 46.7 % of patient was considered to be effective lowering of their BP,another 45% of patient was considered to be more effective.The tolol effective rate was 91.7 %.14 patiants ( 11.6 %) suffered from side effect (dizziness,headache,flush and palpitation) of this drug,but their symptoms were mild and it was unnecessary to withdraw the drug.Heart rate no changed.The biochemical index,liver and kidney function of all patients had no change.Conclusion:Lacidipine had better antihypertentive effect on mild to moderate essential hypertension patients.It′s side effect was scarce but the tolerance was quite good.
出处
《临床心血管病杂志》
CSCD
北大核心
2000年第6期253-255,共3页
Journal of Clinical Cardiology
关键词
拉西地平
高血压
药物疗法
安全性
Lacidipine Hypertension Calcium channel blockers
