摘要
目的检测分析急性下呼吸道感染患儿的病原菌分布及耐药性,为合理的临床用药提供参考依据。方法对医院2009年3月-2011年3月收治的1108例急性下呼吸道感染患儿的痰标本进行细菌培养、菌株鉴定及药敏试验。结果 1108份痰标本中检出病原菌548株,革兰阴性杆菌389株占70.99%,革兰阳性球菌146株占26.64%,前5位病原菌为肺炎克雷伯菌、大肠埃希菌、铜绿假单胞菌、金黄色葡萄球菌及鲍氏不动杆菌,分别占23.72%、20.99%、12.41%、12.41%及8.21%;肺炎克雷伯菌对氨苄西林耐药率为90.77%,大肠埃希菌对氨苄西林耐药率为91.30%,铜绿假单胞菌对氨苄西林/舒巴坦、磺胺甲噁唑/甲氧苄啶的耐药率均为100.00%,金黄色葡萄球菌对青霉素、磺胺甲噁唑/甲氧苄啶耐药率均为91.18%,鲍氏不动杆菌对氨苄西林耐药率为91.11%。结论急性下呼吸道感染的主要致病菌是革兰阴性杆菌,且呈多药耐药性,临床上应尽早做细菌学检测,合理选择抗菌药物。
OBJECTIVE To investigate the pathogenic bacteria and drug resistance of pathogenic bacteria in children with acute lower respiratory tract infections so as to provide reference for reasonable clinical use of antibiotics.METHODS A total of 1108 children with acute lower respiratory tract infections were enrolled in the study from Mar 2009 to Mar 2011,the bacterial culture for the sputum bacterial culture and drug resistance test for the 1108 cases of children with LRTI admitted to our hospital from March 2009 to March 2011.RESULTS A total of 548 strains of pathogens were isolated from 1108 sputum specimens,there were 389（70.99%） strains of gram-negative bacilli,and 146（26.64%） strains of gram-positive cocci;the top five pathogenic bacteria were Klebsiella pneumonia（23.72%）,Escherichia coli（20.99%）,Pseudomonas aeruginosa（12.41%）,and Staphylococcus aureus（12.41%）,and Acinetobacter baumanii（8.21%）;the drug resistance rate of K.pneumonia to ampicillin was 90.77%,91.30% to E.coli,91.11% to A.baumanii,the drug resistance rates of P.aeruginosa to ampicillin/sulbactam and sulfamethoxazole/trimethoprim were 100.00%,and the drug resistance rates of S.aureus to penicillin and sulfamethoxazole/trimethoprim were 91.18%.CONCLUSION Gram-negative bacilli are the main pathogens causing acute lower respiratory tract infections,which are multidrug-resistant;it is necessary to carry out the bacteriology test so as to reasonably select antibiotics.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2012年第24期5640-5642,共3页
Chinese Journal of Nosocomiology
关键词
急性下呼吸道感染
痰培养
药敏检测
Acute lower respiratory tract infection
Sputum culture
Drug susceptibility testing
