摘要
合成了8种三苯基锗杂环羧酸酯Ph_3GeO_2CR(R=2-呋喃基、2-呋喃乙烯基、2-噻吩基、2-吡啶基、3-吡啶基、4-吡啶基、3-吲哚甲基、3-吲哚丙基),利用元素分析、红外光谱、核磁共振氢谱和质谱表征了这些化合物的结构。体外实验表明,这些化合物对MCF-7和WiDr癌细胞具有较好的抑制活性。
Eight new triphenylgermanium heterocyclic carboxylates PlijGeO2CR were synthesized by the reaction of
triphenylgermanium chloride with sodium heterocyclic carboxylate, (Ph3GeCl+ RCO2Na→Ph3GeO2CR). Their structures were established by elementary analysis, IR, 1H NMR and MS spectroscopy. The IR spectra showed that in complexes 1- 8 the carboxyl groups were bidentate ligands. The complexes 1,3,6 and 7 give a very strong peak Ph3Ge+ at m/z = 305 as base peak in mass spectra. The complexes (1 - 8) were tested in vitro against two human tumour cell lines, MCF- 7, a mammary tumour, and WiDr, a colon carcinoma. They all display high activity in vitro, much better than cis - platin or triphenylgermanium chloride.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2000年第4期518-521,共4页
Chinese Journal of Organic Chemistry
基金
山东省自然科学基金(Q98B01117)
晶体材料国家重点实验室资助课题
