摘要
目的探讨甲状腺素联合持续气道正压通气（CPAP）在治疗阻塞性睡眠呼吸暂停低通气综合征（OSAHS）中的疗效，提高临床诊治水平。方法对81例患有OSAHS患者随即分成两组（治疗组43例，对照组38例），两组应用不同诊治方式，对治疗后多导睡眠图监测数据进行回顾性分析。结果两组患者在各研究时间段（治疗前，治疗3个月后，治疗6个月后，治疗12个月后）一般精神状态、AHI、治疗组的SaO2在同组内比较均较前阶段有明显改善，AHI和治疗组的SaO2在各研究时间段比较差异有统计学意义（P〈0．05）。两组患者在研究的相同时间段内比较，AHI在各研究时间段两组比较差异均有统计学意义；两组患者的SO2在治疗6个月后和治疗12个月后比较差异有统计学意义（P〈0．05）。治疗组BMI在各研究时间段内组间比较差异均有统计学意义（P〈0．05），而对照组在前半年组间比较差异有统计学意义（P〈0．05），半年后组间比较则差异无统计学意义。结论OSAHS患者在CPAP治疗基础上口服小剂量甲状腺素治疗效果更好。
Objective To explore the effect of thyroxine joint continuing positive airway pressure （CPAP） in the treatment of obstructive sleep apnea hypopnea syndrome （OSAHS） ,and improve the level of clinic diagnosis and treatment. Methods 81 cases of patients suffering from OSAHS were randomly divided into two groups （43 in the treatment group, and 38 in the control group）, to which two different diagnosis and treatment modalities were applied respectively. Then retrospectively analyzed the monitoring data of polysomnography （PSG） after the treatment. Results In the study period （before treatment,3 months,6 months and 12 months after treatment）, the general state of mind, AHI of both groups and the SaO2 of the treatment group （compared in the same group） were all better than the previous stages, and there were significant differences between AHI and SaO2 of the treatment group （ P〈0.05）. In the same study period, there were significance to AHI between two groups. There were significance to SO2 of both groups 6 months later and 12 months later after the treatment （ P〈0.05）. There were significant differences in BMI of the treatment group between two groups in all study period （P〈0.05）, while there were significant differences of the other group during the first six months （ P〈0.05）, and no significant differences six months later. Conclusions On the basis of CPAP treatment, Oral administration of small doses of thyroxine is better for patients of OSAHS.
出处
《国际呼吸杂志》
2012年第23期1788-1790,共3页
International Journal of Respiration
