摘要
目的了解黑龙江省部分地区格林-巴利综合征(GBS)和急性播散性脑脊髓炎(ADEM)的发病原因及流行病学特征,估计GBS和ADEM人群、年龄别及性别基础发生率,判定其发生与预防接种存在的因果关联,评估预防接种异常反应中该类疾病的发生风险,为开展严重疑似预防接种异常反应调查诊断与处理提供参考依据。方法采用分层多阶段整群抽样方法,选择哈尔滨市、佳木斯市和牡丹江市所有县(区)县级及以上的公立医院、二级甲等及以上民营的综合医院和神经系统疾病专科医院开展病例搜索和回顾性调查。结果共搜索2008-2010年符合病例定义的GBS病例205例,发生率为0.45/10万。其中男性111例,发生率为0.48/10万;女性94例,发生率为0.42/10万。ADEM病例147例,发生率为0.33/10万。其中男性66例,发生率为0.29/10万;女性81例,发生率为0.36/10万。GBS的多发年龄为5～9岁、35～39岁和50～54岁。发病无明显季节性。ADEM各年龄段均有发病,以45～49岁、55～59岁和40～44岁为主。发病无明显季节性。GBS和ADEM的职业分布中以农民、学生和家庭待业为主。结论大部分GBS和ADEM病例的发病原因很难判定,部分病例跟病毒感染存在一定的因果关系。GBS和ADEM的发生与预防接种的时间无明显关联,未发现预防接种后增加GBS和ADEM的发生风险。
Objective To know causes of disease and epidemiological characteristics of Guillain-Barr6 syndrome （GBS） and acute disseminated Encephalomyelitis （ADEM） in parts of regions of Heilongjiang province, and to estimate whole population and age, gender-based incidence, and to provide the scientific evidence for AEFI risk assessment and develope the investigation and diagnosis of severe AEFI. Methods Using stratified multistage cluster sampling method, Harbin, Jiamusi and Mudanjiang cities were chosen in the study and case search and retrospective interview were developed in medical sectors. Cases search and investigation were clone in all public hospitals with county-level or up, private general hospitals with secondary level or up, and specialized hospitals.Results 205 cases investigated from 2008 to 2010 met the case definition of GBS cases with the rate of 0.45/100,000, of which 111 cases were male with the incidence of 0.481100,000 and 94 cases were female with the incidence of 0.421100,000, There were 147 ADEM cases with the incidence of 0.33/100,000, in which 66 cases were male with incidence of 0.29/100,000 and 81 eases were female with incidence rate of 0.36/100,000. Most GBS of eases happened in the age group of 5~9 years, 35~39 years and 50~54 years.No significant seasonal incidence.Most ADEM of cases happened in the age group of 45~49 years, 55~59 years and 40~44 years.Most of GBS and ADEM occupation distributied to farmer,students, and. unemployed. Conclusion It is difficult to determine the causes of the majority of GBS and ADEM cases, but there was causal link of parts of cases and viruses infection.There is no obvious association between GBS and ADEM occurrence and vaccination time, not found after vaccination increased GBS and ADEM risk.
出处
《中国公共卫生管理》
2012年第6期783-784,共2页
Chinese Journal of Public Health Management
