摘要
目的探讨超促排卵(COH)过程中加用电针干预对体外受精—胚胎移植(IVF-ET)患者卵子质量及妊娠结局的影响。方法选择接受IVF-ET的患者224例,其中多囊卵巢综合征(PCOS)141例,非PCOS 83例。将P-COS患者和非PCOS患者分别分为电针组与对照组,均给予促性腺激素释放激素激动剂(GnRH-a)长方案进行COH,电针组加用电针干预,取穴关元、中极、三阴交、子宫、太溪、丰隆。比较各组的妊娠结局。结果 PCOS患者电针组临床妊娠率较对照组提高10.78%,受精率、卵裂率、优质胚胎率较对照组变化明显(P均<0.05);非PCOS患者两组相关指标无明显差异,妊娠组血清、卵泡液SCF水平高于非妊娠组(P<0.05)。结论对IVF-ET患者在COH过程中进行电针干预可提高临床妊娠率,PCOS患者对电针刺激较非PCOS患者敏感。
Objective To investigate the effects of electro-acupuncture（EA） treatment during COH on oocyte quality and the pregnant outcome of the patients undergoing in-vitro- fertilization and embryo transfer （IVF-ET）. Methods Total- ly 224 patients undergoing IVF-ET, in which, there was 141 cases with PCOS, 83 cases with no-PCOS. They were divided into EA group and control group randomly. They all were given ethinylestradiol and cyproterone acetate tablets and long pro- gram ovarian hyperstimulation with gonadotropin-releasing hormone agonist. At the same time, the EA group received EA treatment, and the pregnancy outcome of the two groups was compared. Results The pregnancy rate in EA group of POCS patients was increased by 10.78% than that in control group, and the fertilization rate, egg spliting rate, high grade oocyte rate were increased significantly in EA group（ all P 〈0. 05）. But there were no obvious changes in two groups of no-POCS about those indexes. The levels of SCF in serum, liquor folliculi of pregnancy group were higher than those of non-pregnan- cy group obviously（ all P 〈 0.05 ）. Conclusions Electro-acupuncture used in COH can increase the pregnancy rate in P- COS patients undergoing IVF-ET. The PCOS patients were more sensitive to electro-acupuncture stimulus than the no-PCOS patients.
出处
《山东医药》
CAS
2012年第37期7-10,共4页
Shandong Medical Journal
基金
国家自然科学基金资助项目(30973790)
关键词
多囊卵巢综合征
体外受精-胚胎移植
电针
干细胞因子
polycystic ovary syndrome
in-vitro-fertilization and embryo transfer
electro-acupuncture
stem cell factor
