摘要
目的探讨白细胞介素-20在类风湿关节炎患者血清中的表达及影响因素。方法根据病情,将50例类风湿性关节炎患者分为活动期类风湿性关节炎组、缓解期类风湿性关节炎组,并设立对照组,通过酶联免疫吸附法检测其血清白介素-20水平并与红细胞沉降率、C反应蛋白、晨僵时间等临床生化指标间的关系。结果与对照组相比,类风湿性关节炎患者血清白介素-20水平明显升高(P<0.05)且以活动期类风湿性关节炎患者尤甚(P<0.05);血清白介素-20与晨僵时间、关节压痛指数、红细胞沉降率、C反应蛋白类风湿因子及X线分期均有相关性(P<0.05)。结论 IL-20可能与类风湿性关节炎的发生发展相关,并在一定程度上反映了类风湿性关节炎的活动情况。
Objective To explore the expression of serum IL - 20 and its influencing factors in patients with rheumatoid arthritis. Meth- ods Patients with rheumatoid arthritis were divided into RA in active phase group and RA in alleviative phase group according to condition of ill- ness, and control group was established at the same time. Serum level of IL - 20 had been examined, and relationship between serum level of IL - 20 and＇ clinical and biochemical indicators such as ESR, CRP, duration of morning stuffing etc were compared and analyzed. Results Serum level of IL - 20 in RA patients was significantly elevated compared with that of control group （ P 〈 O. 05 ）, even it was much higher in patients with RA in active phase （ P 〈 O. 05 ） ; and serum level of lL - 20 was closely correlated to duration of morning stuffing, joint pain index, ESR , CRP , RF and X - ray staging. Conclusion Serum level of IL - 20 is probably related to the occurrence and development of rheumatoid arthritis, and it in a certain extent may reflect the activity of rheumatoid arthritis.
出处
《临床和实验医学杂志》
2012年第24期1936-1937,共2页
Journal of Clinical and Experimental Medicine
