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青年乳腺癌患者41例ER、PR、CerbB-2、PCNA的表达及临床特征 被引量:2

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摘要 目的探讨青年乳腺癌患者雌激素受体(ER)、孕激素受体(PR)、原癌基因CerbB-2、增殖细胞核抗原(PCNA)的表达情况、临床特征及其关系。方法应用免疫组化sP法检测41例青年乳腺癌患者ER、PR、CerbB-2及PCNA的表达情况,并与同期328例中老年乳腺癌患者相关指标进行比较。结果41例青年乳腺癌患者ER、PR、cerhB-2及PCNA的表达率分剐为41.46%、53.66%、63.41%、82.93%,中老年组分别为72.87%、58.83%、58.84%、64.94%。青年乳腺癌ER表达低于中老年组(P〈0.01),而PCNA表达则高于中老年组(P〈0.05)。结论青年乳腺癌组织分化差,增殖快,侵袭性强,预后差,ER低表达而PCNA高表达,建议对青年乳腺癌患者同时检测ER、PR、CerhB-2及PCNA。
作者 丁艳
出处 《中国实用医刊》 2012年第23期102-103,共2页 Chinese Journal of Practical Medicine
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